Bradley R Miller
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Explore the profile of Bradley R Miller including associated specialties, affiliations and a list of published articles.
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22
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Recent Articles
1.
Paquelet G, Carrion K, Lacefield C, Zhou P, Hen R, Miller B
STAR Protoc
. 2023 Feb;
4(1):102074.
PMID: 36853724
In vivo brainstem imaging with miniature microscopy has been challenging due to surgical difficulty, high motion, and correlated activity between neurons. Here, we present a protocol for brainstem imaging in...
2.
Paquelet G, Carrion K, Lacefield C, Zhou P, Hen R, Miller B
Neuron
. 2022 Jun;
110(16):2664-2679.e8.
PMID: 35700737
The serotonin system modulates a wide variety of emotional behaviors and states, including reward processing, anxiety, and social interaction. To reveal the underlying patterns of neural activity, we visualized serotonergic...
3.
Miller J, Miller B, ONeil D, Yuste R
Cell Rep
. 2022 Apr;
39(4):110751.
PMID: 35476991
The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations...
4.
5.
Shi C, Miller B, Alexander E, Gulick A, Aldrich C
ACS Chem Biol
. 2020 Jun;
15(7):1813-1819.
PMID: 32568518
Nonribosomal peptide synthetases (NRPSs) are remarkable modular enzymes that synthesize peptide natural products. The condensation (C) domain catalyzes the key amide bond-forming reaction, but structural characterization with bound donor and...
6.
Miller B, Kung Y
PLoS One
. 2018 Dec;
13(12):e0208419.
PMID: 30521590
Mevalonate kinase (MK) is a key enzyme of the mevalonate pathway, which produces the biosynthetic precursors for steroids, including cholesterol, and isoprenoids, the largest class of natural products. Currently available...
7.
Miller B, Kung Y
Biochemistry
. 2017 Dec;
57(5):654-662.
PMID: 29224355
The key mevalonate pathway enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) uses the cofactor NAD(P)H to reduce HMG-CoA to mevalonate in the production of countless metabolites and natural products. Although...
8.
Miller B, Drake E, Shi C, Aldrich C, Gulick A
J Biol Chem
. 2016 Sep;
291(43):22559-22571.
PMID: 27597544
Nonribosomal peptide synthetases (NRPSs) produce a wide variety of peptide natural products. During synthesis, the multidomain NRPSs act as an assembly line, passing the growing product from one module to...
9.
Miller B, Gulick A
Methods Mol Biol
. 2016 Feb;
1401:3-29.
PMID: 26831698
The nonribosomal peptide synthetases are modular enzymes that catalyze synthesis of important peptide products from a variety of standard and non-proteinogenic amino acid substrates. Within a single module are multiple...
10.
Drake E, Miller B, Shi C, Tarrasch J, Sundlov J, Allen C, et al.
Nature
. 2016 Jan;
529(7585):235-8.
PMID: 26762461
Many important natural products are produced by multidomain non-ribosomal peptide synthetases (NRPSs). During synthesis, intermediates are covalently bound to integrated carrier domains and transported to neighbouring catalytic domains in an...