Benoit Coulombe
Overview
Explore the profile of Benoit Coulombe including associated specialties, affiliations and a list of published articles.
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Articles
78
Citations
2985
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Recent Articles
1.
Hashimoto-Roth E, Forget D, Gaspar V, Gaspar V, Bennett S, Gauthier M, et al.
J Proteome Res
. 2025 Jan;
24(2):383-396.
PMID: 39772751
Immunoprecipitation coupled to tandem mass spectrometry (IP-MS/MS) methods are often used to identify protein-protein interactions (PPIs). While these approaches are prone to false positive identifications through contamination and antibody nonspecific...
2.
Coulombe B, Chapleau A, Macintosh J, Durcan T, Poitras C, Moursli Y, et al.
Biomolecules
. 2024 Jul;
14(7).
PMID: 39062571
Cell-based interception and precision medicine is a novel approach aimed at improving healthcare through the early detection and treatment of diseased cells. Here, we describe our recent progress towards developing...
3.
Coulombe B, Durcan T, Bernard G, Moursli A, Poitras C, Faubert D, et al.
Mol Brain
. 2024 Apr;
17(1):18.
PMID: 38605409
One of the main burdens in the treatment of diseases is imputable to the delay between the appearance of molecular dysfunctions in the first affected disease cells and their presence...
4.
Chofflet N, Naito Y, Pastore A, Padmanabhan N, Nguyen P, Poitras C, et al.
Front Mol Neurosci
. 2024 Apr;
17:1371145.
PMID: 38571813
The prevailing model behind synapse development and specificity is that a multitude of adhesion molecules engage in transsynaptic interactions to induce pre- and postsynaptic assembly. How these extracellular interactions translate...
5.
Luo H, Lao L, Au K, Northrup H, He X, Forget D, et al.
Genome Biol
. 2024 Jan;
25(1):19.
PMID: 38225631
Background: Neural tube defects (NTDs) are caused by genetic and environmental factors. ARMC5 is part of a novel ubiquitin ligase specific for POLR2A, the largest subunit of RNA polymerase II...
6.
Macintosh J, Perrier S, Pinard M, Tran L, Guerrero K, Prasad C, et al.
Front Neurol
. 2023 Nov;
14:1254140.
PMID: 37915380
RNA polymerase III-related leukodystrophy (POLR3-related leukodystrophy) is a rare, genetically determined hypomyelinating disease arising from biallelic pathogenic variants in genes encoding subunits of RNA polymerase III (Pol III). Here, we...
7.
Pinard M, Moursli A, Coulombe B
Expert Opin Drug Discov
. 2023 Oct;
19(1):57-71.
PMID: 37840283
Introduction: The PAQosome is a 12-subunit complex that acts as a co-factor of the molecular chaperones HSP90 and HSP70. This co-chaperone has been shown to participate in assembly and maturation...
8.
Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy
Michell-Robinson M, Watt K, Grouza V, Macintosh J, Pinard M, Tuznik M, et al.
Brain
. 2023 Aug;
146(12):5070-5085.
PMID: 37635302
RNA polymerase III (Pol III)-related hypomyelinating leukodystrophy (POLR3-HLD), also known as 4H leukodystrophy, is a severe neurodegenerative disease characterized by the cardinal features of hypomyelination, hypodontia and hypogonadotropic hypogonadism. POLR3-HLD...
9.
Pinard M, Dastpeyman S, Poitras C, Bernard G, Gauthier M, Coulombe B
Mol Brain
. 2022 Nov;
15(1):98.
PMID: 36451185
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood....
10.
Sudarshan D, Avvakumov N, Lalonde M, Alerasool N, Joly-Beauparlant C, Jacquet K, et al.
Genes Dev
. 2022 Jun;
36(11-12):664-683.
PMID: 35710139
Chromosomal translocations frequently promote carcinogenesis by producing gain-of-function fusion proteins. Recent studies have identified highly recurrent chromosomal translocations in patients with endometrial stromal sarcomas (ESSs) and ossifying fibromyxoid tumors (OFMTs),...