Towards a Treatment for Leukodystrophy Using Cell-Based Interception and Precision Medicine

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2024 Jul 27

PMID 39062571

Authors

Benoit Coulombe

Alexandra Chapleau

Julia Macintosh

Thomas M Durcan

Christian Poitras

Yena A Moursli

Denis Faubert

Maxime Pinard

Genevieve Bernard

Affiliations

Soon will be listed here.

Abstract

Cell-based interception and precision medicine is a novel approach aimed at improving healthcare through the early detection and treatment of diseased cells. Here, we describe our recent progress towards developing cell-based interception and precision medicine to detect, understand, and advance the development of novel therapeutic approaches through a single-cell omics and drug screening platform, as part of a multi-laboratory collaborative effort, for a group of neurodegenerative disorders named leukodystrophies. Our strategy aims at the identification of diseased cells as early as possible to intercept progression of the disease prior to severe clinical impairment and irreversible tissue damage.

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