Benjamin P Hurrell
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Explore the profile of Benjamin P Hurrell including associated specialties, affiliations and a list of published articles.
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37
Citations
892
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Recent Articles
1.
Kazemi M, Momeni-Varposhti Z, Li X, Hurrell B, Sakano Y, Shen S, et al.
J Clin Invest
. 2025 Jan;
135(4).
PMID: 39745792
Group 2 innate lymphoid cells (ILC2s) play a pivotal role in the development of airway hyperreactivity (AHR). However, the regulatory mechanisms governing ILC2 function remain inadequately explored. This study uncovers...
2.
Goris M, Passelli K, Peyvandi S, Diaz-Varela M, Billion O, Prat-Luri B, et al.
PLoS Pathog
. 2024 Sep;
20(9):e1012527.
PMID: 39250503
Intracellular pathogens that replicate in host myeloid cells have devised ways to inhibit the cell's killing machinery. Pyroptosis is one of the host strategies used to reduce the pathogen replicating...
3.
Sakano Y, Sakano K, Hurrell B, Shafiei-Jahani P, Kazemi M, Li X, et al.
Cell Mol Immunol
. 2024 Aug;
21(10):1158-1174.
PMID: 39160226
Group-2 innate lymphoid cells (ILC2) are part of a growing family of innate lymphocytes known for their crucial role in both the development and exacerbation of allergic asthma. The activation...
4.
Shafiei-Jahani P, Yan S, Kazemi M, Li X, Akbari A, Sakano K, et al.
Cell Rep
. 2024 Jul;
43(7):114434.
PMID: 38963763
Development of type 2 diabetes mellitus (T2DM) is associated with low-grade chronic type 2 inflammation and disturbance of glucose homeostasis. Group 2 innate lymphoid cells (ILC2s) play a critical role...
5.
Hurrell B, Sakano Y, Shen S, Helou D, Li M, Shafiei-Jahani P, et al.
Sci Transl Med
. 2024 May;
16(746):eadk4728.
PMID: 38718131
Group 2 innate lymphoid cells (ILC2s) rapidly induce a type 2 inflammation in the lungs in response to allergens. Here, we focused on the role of iron, a critical nutritional...
6.
Hurrell B, Shen S, Li X, Sakano Y, Kazemi M, Quach C, et al.
J Exp Med
. 2024 Mar;
221(5).
PMID: 38530239
Mechanosensitive ion channels sense force and pressure in immune cells to drive the inflammatory response in highly mechanical organs. Here, we report that Piezo1 channels repress group 2 innate lymphoid...
7.
Li Y, Wu C, Lee J, Ning Q, Lim J, Eoh H, et al.
PLoS Pathog
. 2024 Mar;
20(3):e1012079.
PMID: 38466743
Macrophages can undergo M1-like proinflammatory polarization with low oxidative phosphorylation (OXPHOS) and high glycolytic activities or M2-like anti-inflammatory polarization with the opposite metabolic activities. Here we show that M1-like macrophages...
8.
Sakano Y, Sakano K, Hurrell B, Helou D, Shafiei-Jahani P, Kazemi M, et al.
J Allergy Clin Immunol
. 2024 Jan;
153(5):1406-1422.e6.
PMID: 38244725
Background: Type 2 innate lymphoid cells (ILC2s) play a pivotal role in type 2 asthma. CD226 is a costimulatory molecule involved in various inflammatory diseases. Objective: We aimed to investigate...
9.
Howard E, Hurrell B, Helou D, Shafiei-Jahani P, Hasiakos S, Painter J, et al.
Nat Commun
. 2023 Sep;
14(1):5989.
PMID: 37752127
Ca entry via Ca release-activated Ca (CRAC) channels is a predominant mechanism of intracellular Ca elevation in immune cells. Here we show the immunoregulatory role of CRAC channel components Orai1...
10.
Helou D, Quach C, Hurrell B, Li X, Li M, Akbari A, et al.
Mucosal Immunol
. 2023 Aug;
16(6):788-800.
PMID: 37634572
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious health problems that manifest as acute respiratory failure in response to different conditions, including viral respiratory infections. Recently,...