Benjamin J Shields
Overview
Explore the profile of Benjamin J Shields including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
1274
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0
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Recent Articles
1.
Tremblay C, Saw J, Yan F, Boyle J, Amarasinghe O, Abdollahi S, et al.
Leukemia
. 2025 Jan;
39(3):577-589.
PMID: 39849166
Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is an immature subtype of T-cell acute lymphoblastic leukemia (T-ALL) commonly show deregulation of the LMO2-LYL1 stem cell transcription factors, activating mutations of...
2.
Wang J, Stevens J, Kariofillis S, Tom M, Golden D, Li J, et al.
Nature
. 2024 Feb;
626(8001):1025-1033.
PMID: 38418912
Reaction conditions that are generally applicable to a wide variety of substrates are highly desired, especially in the pharmaceutical and chemical industries. Although many approaches are available to evaluate the...
3.
Wiede F, Shields B, Kyparissoudis S, van Vliet C, Galic S, Tremblay M, et al.
J Clin Invest
. 2023 Oct;
133(20).
PMID: 37843283
No abstract available.
4.
Zuranski A, Martinez Alvarado J, Shields B, Doyle A
Acc Chem Res
. 2021 Mar;
54(8):1856-1865.
PMID: 33788552
Numerous disciplines, such as image recognition and language translation, have been revolutionized by using machine learning (ML) to leverage big data. In organic synthesis, providing accurate chemical reactivity predictions with...
5.
Shields B, Stevens J, Li J, Parasram M, Damani F, Martinez Alvarado J, et al.
Nature
. 2021 Feb;
590(7844):89-96.
PMID: 33536653
Reaction optimization is fundamental to synthetic chemistry, from optimizing the yield of industrial processes to selecting conditions for the preparation of medicinal candidates. Likewise, parameter optimization is omnipresent in artificial...
6.
Abdulla H, Vo A, Shields B, Davies T, Jackson J, Alserihi R, et al.
Leukemia
. 2021 Jan;
35(8):2205-2219.
PMID: 33483615
The majority of cases of T-cell acute lymphoblastic leukemia (T-ALL) contain chromosomal abnormalities that drive overexpression of oncogenic transcription factors. However, whether these initiating oncogenes are required for leukemia maintenance...
7.
Parasram M, Shields B, Ahmad O, Knauber T, Doyle A
ACS Catal
. 2020 Aug;
10(10):5821-5827.
PMID: 32747870
A cross-electrophile coupling reaction of epoxides and (hetero)aryl iodides that operates via the merger of three catalytic cycles involving a Ni-, Ti-, and organic photoredox catalyst has been developed. Three...
8.
Carmichael C, Wang J, Nguyen T, Kolawole O, Benyoucef A, De Maziere C, et al.
Blood
. 2020 May;
136(8):957-973.
PMID: 32369597
Modulators of epithelial-to-mesenchymal transition (EMT) have recently emerged as novel players in the field of leukemia biology. The mechanisms by which EMT modulators contribute to leukemia pathogenesis, however, remain to...
9.
Kariofillis S, Shields B, Tekle-Smith M, Zacuto M, Doyle A
J Am Chem Soc
. 2020 Apr;
142(16):7683-7689.
PMID: 32275411
Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein...
10.
Ting S, Garakyaraghi S, Taliaferro C, Shields B, Scholes G, Castellano F, et al.
J Am Chem Soc
. 2020 Mar;
142(12):5800-5810.
PMID: 32150401
Synthetic organic chemistry has seen major advances due to the merger of nickel and photoredox catalysis. A growing number of Ni-photoredox reactions are proposed to involve generation of excited nickel...