Jacob T Jackson
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Explore the profile of Jacob T Jackson including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
684
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Recent Articles
1.
Jackson J, Ng A, Nutt S, Ikawa T, Wu L
Front Immunol
. 2024 Jun;
15:1413841.
PMID: 38881890
No abstract available.
2.
Jackson J, Nutt S, McCormack M
Front Immunol
. 2023 Jul;
14:1197490.
PMID: 37398663
The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional repressor that is of fundamental importance across species, as evident by its evolutionary conservation spanning fish, amphibians, birds, mice and...
3.
Mulazzani E, Kong K, Arostegui J, Ng A, Ranathunga N, Abeysekera W, et al.
Nat Immunol
. 2023 Mar;
24(5):814-826.
PMID: 36997670
Missense mutations in PLCG2 can cause autoinflammation with phospholipase C gamma 2-associated antibody deficiency and immune dysregulation (APLAID). Here, we generated a mouse model carrying an APLAID mutation (p.Ser707Tyr) and...
4.
Davidson S, Yu C, Steiner A, Ebstein F, Baker P, Jarur-Chamy V, et al.
Sci Immunol
. 2022 Feb;
7(68):eabi6763.
PMID: 35148201
Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this is currently unknown. Here, we identified...
5.
Jackson J, Mulazzani E, Nutt S, Masters S
J Biol Chem
. 2021 Jun;
297(2):100905.
PMID: 34157287
Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif. These receptors recruit kinases...
6.
Song S, Cao C, Choukrallah M, Tang F, Christofori G, Kohler H, et al.
Blood
. 2021 Jan;
137(21):2920-2934.
PMID: 33512466
OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell-specific and indispensable for germinal center (GC) formation, but their mechanism...
7.
Abdulla H, Vo A, Shields B, Davies T, Jackson J, Alserihi R, et al.
Leukemia
. 2021 Jan;
35(8):2205-2219.
PMID: 33483615
The majority of cases of T-cell acute lymphoblastic leukemia (T-ALL) contain chromosomal abnormalities that drive overexpression of oncogenic transcription factors. However, whether these initiating oncogenes are required for leukemia maintenance...
8.
Fedele P, Liao Y, Gong J, Yao Y, van Delft M, Low M, et al.
Leukemia
. 2020 Nov;
35(7):2114-2118.
PMID: 33149265
No abstract available.
9.
Goh W, Scheer S, Jackson J, Hediyeh-Zadeh S, Delconte R, Schuster I, et al.
Cell Rep
. 2020 Oct;
33(3):108285.
PMID: 33086067
Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development,...
10.
Amann-Zalcenstein D, Tian L, Schreuder J, Tomei S, Lin D, Fairfax K, et al.
Nat Immunol
. 2020 Oct;
21(12):1574-1584.
PMID: 33077975
A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. Linc-KitSca-1Flt3 cells, termed lymphoid-primed multipotent progenitors (LMPPs), have lost...