Christina A Mitchell
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Explore the profile of Christina A Mitchell including associated specialties, affiliations and a list of published articles.
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107
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3014
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Recent Articles
1.
Tham M, Cottle D, Zylberberg A, Short K, Jones L, Chan P, et al.
Nat Commun
. 2024 Jan;
15(1):371.
PMID: 38191531
Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA's role in regulating renal cyst development we conditionally deleted...
2.
Lourdes S, Gurung R, Giri S, Mitchell C, McGrath M
Adv Biol Regul
. 2023 Dec;
91:101001.
PMID: 38057188
Phosphoinositides are a minor group of membrane-associated phospholipids that are transiently generated on the cytoplasmic leaflet of many organelle membranes and the plasma membrane. There are seven functionally distinct phosphoinositides,...
3.
York H, Joshi K, Wright C, Kreplin L, Rodgers S, Moorthi U, et al.
Nat Commun
. 2023 Aug;
14(1):4652.
PMID: 37532690
Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific...
4.
Rodgers S, Mitchell C, Ooms L
Biochem Soc Trans
. 2023 Jul;
51(4):1459-1472.
PMID: 37471270
The class IA PI3K signaling pathway is activated by growth factor stimulation and regulates a signaling cascade that promotes diverse events including cell growth, proliferation, migration and metabolism. PI3K signaling...
5.
Davies E, Gurung R, Le K, Roan K, Harvey R, Mitchell G, et al.
Sci Adv
. 2023 Mar;
9(13):eadd6911.
PMID: 37000875
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P to PI(3,4,5)P, activating AKT;...
6.
Lambouras M, Roelofs C, Pereira M, Gruber E, Vieusseux J, Lanteri P, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982737
Estrogen receptor-positive breast cancers (ER BCas) are the most common form of BCa and are increasing in incidence, largely due to changes in reproductive practices in recent decades. Tamoxifen is...
7.
Rodgers S, Ooms L, Mitchell C
Cancers (Basel)
. 2023 Jan;
15(1).
PMID: 36612130
The majority of breast cancers are estrogen receptor-positive (ER), and endocrine therapies that suppress ER signaling are the standard-of-care treatment for this subset. However, up to half of all ER...
8.
Nanayakkara R, Gurung R, Rodgers S, Eramo M, Ramm G, Mitchell C, et al.
Autophagy
. 2022 Nov;
19(5):1378-1395.
PMID: 36409033
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome repopulation ensures sustained autophagy...
9.
Rodgers S, Jones E, Mitchell C, McGrath M
Autophagy
. 2022 Sep;
19(4):1365-1367.
PMID: 36103410
Macroautophagy/autophagy occurs basally under nutrient-rich conditions in most mammalian cells, contributing to protein and organelle quality control, and protection against aging and neurodegeneration. During autophagy, lysosomes are heavily utilized via...
10.
Rodgers S, Jones E, Arumugam S, Hamila S, Danne J, Gurung R, et al.
EMBO J
. 2022 Aug;
41(19):e110398.
PMID: 35968799
Autophagy depends on the repopulation of lysosomes to degrade intracellular components and recycle nutrients. How cells co-ordinate lysosome repopulation during basal autophagy, which occurs constitutively under nutrient-rich conditions, is unknown....