Benedikt M Kessler
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Explore the profile of Benedikt M Kessler including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Dellar E, Vendrell I, Talbot K, Kessler B, Fischer R, Turner M, et al.
J Neurochem
. 2023 Dec;
168(2):115-127.
PMID: 38087504
While unbiased proteomics of human cerebrospinal fluid (CSF) has been used successfully to identify biomarkers of amyotrophic lateral sclerosis (ALS), high-abundance proteins mask the presence of lower abundance proteins that...
22.
Gan J, Pinto-Fernandez A, Flierman D, Akkermans J, OBrien D, Greenwood H, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(50):e2315163120.
PMID: 38055744
Interferon-induced ubiquitin (Ub)-like modifier ISG15 covalently modifies host and viral proteins to restrict viral infections. Its function is counteracted by the canonical deISGylase USP18 or Ub-specific protease 18. Notwithstanding indications...
23.
Davis S, Scott C, Oetjen J, Charles P, Kessler B, Ansorge O, et al.
Nat Commun
. 2023 Nov;
14(1):7710.
PMID: 38001067
The spatial organisation of cellular protein expression profiles within tissue determines cellular function and is key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue,...
24.
Scott H, Draganov S, Yu Z, Kessler B, Pinto-Fernandez A
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958498
Bioactive lipids are involved in cellular signalling events with links to human disease. Many of these are involved in inflammation under normal and pathological conditions. Despite being attractive molecules from...
25.
Wellington D, Yin Z, Yu Z, Heilig R, Davis S, Fischer R, et al.
Heliyon
. 2023 Oct;
9(10):e20076.
PMID: 37842619
Mutations within viral epitopes can result in escape from T cells, but the contribution of mutations in flanking regions of epitopes in SARS-CoV-2 has not been investigated. Focusing on two...
26.
van Leeuwen L, Ruigrok M, Kessler B, Leuvenink H, Olinga P
Br J Pharmacol
. 2023 Aug;
181(3):464-479.
PMID: 37596999
Background And Purpose: Fibrosis in kidney allografts is a major post-transplant complication that contributes to graft failure. Lately, multiple potent inhibitors of fibrosis-related pathways have been developed such as galunisertib,...
27.
Lassen F, Venkatesh S, Baya N, Zhou W, Bloemendal A, Neale B, et al.
medRxiv
. 2023 Jul;
PMID: 37461573
Exome-sequencing association studies have successfully linked rare protein-coding variation to risk of thousands of diseases. However, the relationship between rare deleterious compound heterozygous (CH) variation and their phenotypic impact has...
28.
Cao Y, Lin Y, Sun N, Du X, Dong Y, Mei S, et al.
Sci China Life Sci
. 2023 Jun;
66(10):2380-2398.
PMID: 37389760
Cross-kingdom herbal miRNA was first reported in 2012. Using a modified herbal extraction protocol, we obtained 73,677,287 sequences by RNA-seq from 245 traditional Chinese Medicine (TCM), of which 20,758,257 were...
29.
OBrien D, Jones H, Guenther F, Murphy E, England K, Vendrell I, et al.
Mol Cell Proteomics
. 2023 Jun;
22(8):100609.
PMID: 37385347
Dampening functional levels of the mitochondrial deubiquitylating enzyme Ubiquitin-specific protease 30 (USP30) has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson's Disease. USP30 inhibition may...
30.
Halner A, Hankey L, Liang Z, Pozzetti F, Szulc D, Mi E, et al.
iScience
. 2023 May;
26(5):106610.
PMID: 37168566
Cancer is a leading cause of mortality worldwide. Over 50% of cancers are diagnosed late, rendering many treatments ineffective. Existing liquid biopsy studies demonstrate a minimally invasive and inexpensive approach...