Philip D Charles
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Explore the profile of Philip D Charles including associated specialties, affiliations and a list of published articles.
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46
Citations
1401
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Recent Articles
1.
Jorsboe E, Kubitz P, Honecker J, Flaccus A, Mvondo D, Raggi M, et al.
medRxiv
. 2025 Feb;
PMID: 39990583
Fat distribution and macro structure of white adipose tissue are important factors in predicting obesity-associated diseases, but cellular microstructure of white adipose tissue has been less explored. To investigate the...
2.
Baya N, Erdem I, Venkatesh S, Reibe S, Charles P, Navarro-Guerrero E, et al.
medRxiv
. 2024 Oct;
PMID: 39371160
Overall adiposity and body fat distribution are heritable traits associated with altered risk of cardiometabolic disease and mortality. Performing rare variant (minor allele frequency<1%) association testing using exome-sequencing data from...
3.
Mi Y, Burnham K, Charles P, Heilig R, Vendrell I, Whalley J, et al.
Sci Transl Med
. 2024 Jun;
16(750):eadh0185.
PMID: 38838133
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of pathophysiology and new therapeutic approaches. Here, we applied high-throughput tandem...
4.
Ayagama T, Charles P, Bose S, Boland B, Priestman D, Aston D, et al.
iScience
. 2024 Jun;
27(6):109609.
PMID: 38827406
Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role...
5.
Morrow G, Flannery S, Charles P, Heilig R, Feller T, McQuilten Z, et al.
J Thromb Haemost
. 2024 Mar;
22(6):1758-1771.
PMID: 38462220
Background: The widespread use of the antifibrinolytic agent, tranexamic acid (TXA), interferes with the quantification of fibrinolysis by dynamic laboratory assays such as clot lysis, making it difficult to measure...
6.
Damianou A, Liang Z, Lassen F, Vendrell I, Vere G, Hester S, et al.
Life Sci Alliance
. 2024 Mar;
7(5).
PMID: 38453365
KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute to ∼30% of human solid tumours, including lung adenocarcinoma, pancreatic, and colorectal carcinomas. Most KRAS activating mutations interfere with GTP...
7.
Davis S, Scott C, Oetjen J, Charles P, Kessler B, Ansorge O, et al.
Nat Commun
. 2023 Nov;
14(1):7710.
PMID: 38001067
The spatial organisation of cellular protein expression profiles within tissue determines cellular function and is key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue,...
8.
Zhang Q, Charles P, Bendif E, Hester S, Mohammad S, Rickaby R
New Phytol
. 2023 Nov;
241(2):676-686.
PMID: 37974482
Marine phytoplankton can interchange trace metals in various biochemical functions, particularly under metal-limiting conditions. Here, we investigate the stimulating and toxicity effect of chromium (Cr) on a marine Chlorophyceae Osetreococcus...
9.
Mulvey J, Shaheed S, Charles P, Snashall C, Faro M, Sutton C, et al.
Ann Surg
. 2023 Jul;
278(5):676-682.
PMID: 37503631
Objective: To provide mechanistic insight into key biological alterations in donation after circulatory death kidneys during continuous pefusion we performed mass spectrometry profiling of perfusate samples collected during a phase...
10.
Rota I, Handel A, Maio S, Klein F, Dhalla F, Deadman M, et al.
Sci Adv
. 2021 Dec;
7(49):eabj9247.
PMID: 34860543
The transcription factor FOXN1 is a master regulator of thymic epithelial cell (TEC) development and function. Here, we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in...