Benedikt M Kessler
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Explore the profile of Benedikt M Kessler including associated specialties, affiliations and a list of published articles.
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286
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12326
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Recent Articles
11.
Ellis M, Lekka C, Holden K, Tulmin H, Seedat F, OBrien D, et al.
Acta Neuropathol
. 2024 May;
147(1):87.
PMID: 38761203
Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in Alzheimer's disease and other dementias, hundreds of distinct antibody clones have...
12.
Olie C, OBrien D, Jones H, Liang Z, Damianou A, Sur-Erdem I, et al.
Biochem Soc Trans
. 2024 May;
52(3):1085-1098.
PMID: 38716888
In vivo, muscle and neuronal cells are post-mitotic, and their function is predominantly regulated by proteostasis, a multilayer molecular process that maintains a delicate balance of protein homeostasis. The ubiquitin-proteasome...
13.
Liang Z, Damianou A, Vendrell I, Jenkins E, Lassen F, Washer S, et al.
Cell Rep
. 2024 Apr;
43(5):114152.
PMID: 38669140
Activation of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome complex is an essential innate immune signaling mechanism. To reveal how human NLRP3 inflammasome assembly and activation are...
14.
Blest H, Redmond A, Avissar J, Barker J, Bridgeman A, Fowler G, et al.
Cell Rep
. 2024 Apr;
43(5):114122.
PMID: 38652659
DNA sensing is important for antiviral immunity. The DNA sensor cGAS synthesizes 2'3'-cyclic GMP-AMP (cGAMP), a second messenger that activates STING, which induces innate immunity. cGAMP not only activates STING...
15.
Jove V, Wheeler H, Lee C, Healy D, Levine K, Ralph E, et al.
iScience
. 2024 Apr;
27(4):109593.
PMID: 38632987
Precise regulation of Type I interferon signaling is crucial for combating infection and cancer while avoiding autoimmunity. Type I interferon signaling is negatively regulated by USP18. USP18 cleaves ISG15, an...
16.
Hamid M, Cespedes P, Jin C, Chen J, Gileadi U, Antoun E, et al.
Nat Immunol
. 2024 Apr;
25(5):834-846.
PMID: 38561495
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103 T cells have...
17.
Imhoff R, Patel R, Safdar M, Jones H, Pinto-Fernandez A, Vendrell I, et al.
J Med Chem
. 2024 Mar;
67(6):4496-4524.
PMID: 38488146
Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer. Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is expressed primarily in the...
18.
Damianou A, Liang Z, Lassen F, Vendrell I, Vere G, Hester S, et al.
Life Sci Alliance
. 2024 Mar;
7(5).
PMID: 38453365
KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute to ∼30% of human solid tumours, including lung adenocarcinoma, pancreatic, and colorectal carcinomas. Most KRAS activating mutations interfere with GTP...
19.
Bello C, Filipovic M, Huber M, Flannery S, Kobel B, Fischer R, et al.
Front Cardiovasc Med
. 2024 Feb;
10:1287724.
PMID: 38379859
Background: Molecular mechanisms underlying perioperative acute phase reactions in cardiac surgery are largely unknown. We aimed to characterise perioperative alterations of the acute phase plasma proteome in a cohort of...
20.
Tsukada K, Jones S, Bannister J, Durin M, Vendrell I, Fawkes M, et al.
Mol Cell
. 2024 Jan;
84(4):640-658.e10.
PMID: 38266639
The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1, and RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA replication intermediates to promote sister...