Holger B Kramer
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Explore the profile of Holger B Kramer including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
1650
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Recent Articles
1.
Zhang T, Wang Y, Montoya A, Patrascan I, Nebioglu N, Pallikonda H, et al.
Blood
. 2024 Oct;
145(4):422-437.
PMID: 39437550
The transcription factor (TF) Ikaros zinc finger 1 (IKZF1) is essential for B-cell development, and recurrently mutated in human B-cell acute lymphoblastic leukemia (B-ALL). IKZF1 has been ascribed both activating...
2.
Park K, Crump N, Louwman N, Krywawych S, Cheong Y, Vendrell I, et al.
Nat Cardiovasc Res
. 2024 Mar;
2:1221-1245.
PMID: 38500966
Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism...
3.
Johnston H, Yadav K, Kirkpatrick J, Biggs G, Oxley D, Kramer H, et al.
Anal Chem
. 2022 Jul;
94(29):10320-10328.
PMID: 35848328
Complete, reproducible extraction of protein material is essential for comprehensive and unbiased proteome analyses. A current gold standard is single-pot, solid-phase-enhanced sample preparation (SP3), in which organic solvent and magnetic...
4.
Leissing T, Hardy A, Chan H, Wang Y, Tumber A, Chowdhury R, et al.
J Biol Chem
. 2022 May;
298(6):102020.
PMID: 35537551
The aspariginyl hydroxylase human factor inhibiting hypoxia-inducible factor (FIH) is an important regulator of the transcriptional activity of hypoxia-inducible factor. FIH also catalyzes the hydroxylation of asparaginyl and other residues...
5.
Needs S, Bootman M, Grotzke J, Kramer H, Allman S
FEBS J
. 2022 Jan;
289(11):3115-3131.
PMID: 34995415
The polycaspase inhibitor Z-VAD-fmk acts as an inhibitor of peptide: N-glycanase (NGLY1), an endoglycosidase which cleaves N-linked glycans from glycoproteins exported from the endoplasmic reticulum (ER) during ER-associated degradation (ERAD)....
6.
Taylor N, Hessman G, Kramer H, McGouran J
Chem Sci
. 2021 Jun;
11(11):2967-2972.
PMID: 34122797
Deubiquitinating enzymes (DUBs) are known to have numerous important interactions with the ubiquitin cascade and their dysregulation is associated with several diseases, including cancer and neurodegeneration. They are an important...
7.
Newton H, Wang Y, Camplese L, Mokochinski J, Kramer H, Brown A, et al.
Nat Commun
. 2020 Sep;
11(1):4653.
PMID: 32938923
Cancer cells demand excess nutrients to support their proliferation, but how tumours exploit extracellular amino acids during systemic metabolic perturbations remain incompletely understood. Here, we use a Drosophila model of...
8.
van Dam E, van Leeuwen L, Dos Santos E, James J, Best L, Lennicke C, et al.
Cell Metab
. 2020 Mar;
31(4):710-725.e7.
PMID: 32197072
High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival...
9.
Beier L, Rossa J, Woodhouse S, Bergmann S, Kramer H, Protze J, et al.
Int J Mol Sci
. 2019 Sep;
20(19).
PMID: 31561440
Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1)....
10.
Hudry B, de Goeij E, Mineo A, Gaspar P, Hadjieconomou D, Studd C, et al.
Cell
. 2019 Aug;
178(4):901-918.e16.
PMID: 31398343
Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to investigate how gut-derived signals contribute to sex...