Bayan Mashahreh
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Explore the profile of Bayan Mashahreh including associated specialties, affiliations and a list of published articles.
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10
Citations
105
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Recent Articles
1.
Mashahreh B, Armony S, Ravid T
Biomolecules
. 2023 Jun;
13(6).
PMID: 37371568
Quality control-associated proteolysis (QCAP) is a fundamental mechanism that maintains cellular homeostasis by eliminating improperly folded proteins. In QCAP, the exposure of normally hidden -acting protein sequences, termed degrons, triggers...
2.
Johansson K, Mashahreh B, Hartmann-Petersen R, Ravid T, Lindorff-Larsen K
J Mol Biol
. 2022 Dec;
435(2):167915.
PMID: 36495918
Effective proteome homeostasis is key to cellular and organismal survival, and cells therefore contain efficient quality control systems to monitor and remove potentially toxic misfolded proteins. Such general protein quality...
3.
Mashahreh B, Armony S, Johansson K, Chappleboim A, Friedman N, Gardner R, et al.
Nat Commun
. 2022 Dec;
13(1):7588.
PMID: 36481666
The eukaryotic proteome undergoes constant surveillance by quality control systems that either sequester, refold, or eliminate aberrant proteins by ubiquitin-dependent mechanisms. Ubiquitin-conjugation necessitates the recognition of degradation determinants, termed degrons,...
4.
Amar-Schwartz A, Ben Hur V, Jbara A, Cohen Y, Barnabas G, Arbib E, et al.
Elife
. 2022 Oct;
11.
PMID: 36189922
The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis, and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling...
5.
Mashahreh B, Reiss Y, Wiener R, Ravid T
Methods Enzymol
. 2019 Mar;
619:71-95.
PMID: 30910030
Ubiquitin (Ub)-mediated protein degradation is a key cellular defense mechanism that detects and eliminates defective proteins. A major intracellular site of protein quality control degradation is the endoplasmic reticulum (ER),...
6.
Soudah N, Padala P, Hassouna F, Kumar M, Mashahreh B, Lebedev A, et al.
J Mol Biol
. 2018 Nov;
431(3):463-478.
PMID: 30412706
Modification of proteins by the ubiquitin-like protein, UFM1, requires activation of UFM1 by the E1-activating enzyme, UBA5. In humans, UBA5 possesses two isoforms, each comprising an adenylation domain, but only...
7.
Mashahreh B, Hassouna F, Soudah N, Cohen-Kfir E, Strulovich R, Haitin Y, et al.
FASEB J
. 2018 Jan;
32(5):2794-2802.
PMID: 29295865
All ubiquitin-like proteins (UBLs) undergo an activation process before their conjugation to target proteins. Although the steps required for the activation of UBLs are conserved and common to all UBLs,...
8.
Padala P, Oweis W, Mashahreh B, Soudah N, Cohen-Kfir E, Todd E, et al.
Sci Rep
. 2017 Apr;
7(1):508.
PMID: 28360427
The modification of proteins by ubiquitin-fold modifier 1 (UFM1) is implicated in many human diseases. Prior to conjugation, UFM1 undergoes activation by its cognate activating enzyme, UBA5. UBA5 is a...
9.
Attali I, Tobelaim W, Persaud A, Motamedchaboki K, Simpson-Lavy K, Mashahreh B, et al.
EMBO J
. 2017 Jan;
36(4):425-440.
PMID: 28069708
Ubiquitylation controls protein function and degradation. Therefore, ubiquitin ligases need to be tightly controlled. We discovered an evolutionarily conserved allosteric restraint mechanism for Nedd4 ligases and demonstrated its function with...
10.
Baiady N, Padala P, Mashahreh B, Cohen-Kfir E, Todd E, Du Pont K, et al.
J Biol Chem
. 2015 Nov;
291(4):2033-2042.
PMID: 26601948
The deubiquitinating enzyme associated molecule with the SH3 domain of STAM (AMSH) is crucial for the removal of ubiquitin molecules during receptor-mediated endocytosis and lysosomal receptor sorting. AMSH interacts with...