Kresten Lindorff-Larsen
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Explore the profile of Kresten Lindorff-Larsen including associated specialties, affiliations and a list of published articles.
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9232
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Recent Articles
1.
von Bulow S, Tesei G, Lindorff-Larsen K
Curr Opin Struct Biol
. 2025 Mar;
92:103028.
PMID: 40081192
Recent years have seen tremendous developments in the use of machine learning models to link amino-acid sequence, structure, and function of folded proteins. These methods are, however, rarely applicable to...
2.
Yasuda I, von Bulow S, Tesei G, Yamamoto E, Yasuoka K, Lindorff-Larsen K
J Chem Theory Comput
. 2025 Feb;
21(5):2766-2779.
PMID: 40009520
Protein-RNA condensates are involved in a range of cellular activities. Coarse-grained molecular models of intrinsically disordered proteins have been developed to shed light on and predict single-chain properties and phase...
3.
Larsen J, Barclay A, Vettore N, Klausen L, Mangels L, Coden A, et al.
Nat Chem
. 2025 Jan;
17(3):403-411.
PMID: 39820805
Amyloid fibrils are highly stable misfolded protein assemblies that play an important role in several neurodegenerative and systemic diseases. Although structural information of the amyloid state is now abundant, mechanistic...
4.
Gersing S, Hansen T, Lindorff-Larsen K, Hartmann-Petersen R
Trends Biochem Sci
. 2025 Jan;
50(3):255-266.
PMID: 39753435
Human glucokinase (GCK) functions as a glucose sensor in the pancreas and liver, where GCK activity regulates insulin secretion and glycogen synthesis, respectively. GCK's low affinity for glucose and the...
5.
Cortes Rodriguez F, Frattini G, Phloi-Montri S, Meireles F, Terrien D, Cruz-Leon S, et al.
J Mol Graph Model
. 2024 Dec;
135():108932.
PMID: 39719805
MolecularWebXR is a new web-based platform for education, science communication and scientific peer discussion in chemistry and biology, based on modern web-based Virtual Reality (VR) and Augmented Reality (AR). With...
6.
Larsen-Ledet S, Lindemose S, Panfilova A, Gersing S, Suhr C, Genzor A, et al.
Structure
. 2024 Dec;
33(2):262-273.e6.
PMID: 39706198
Gene variants resulting in insertions or deletions of amino acid residues (indels) have important consequences for evolution and are often linked to disease, yet, compared to missense variants, the effects...
7.
Cagiada M, Ovchinnikov S, Lindorff-Larsen K
Protein Sci
. 2024 Dec;
34(1):e5233.
PMID: 39673466
While there has been substantial progress in our ability to predict changes in protein stability due to amino acid substitutions, progress has been slower in methods to predict the absolute...
8.
Garcia-Cabau C, Bartomeu A, Tesei G, Cheung K, Pose-Utrilla J, Pico S, et al.
Nature
. 2024 Dec;
637(8045):496-503.
PMID: 39633052
The inclusion of microexons by alternative splicing occurs frequently in neuronal proteins. The roles of these sequences are largely unknown, and changes in their degree of inclusion are associated with...
9.
SSEmb: A joint embedding of protein sequence and structure enables robust variant effect predictions
Blaabjerg L, Jonsson N, Boomsma W, Stein A, Lindorff-Larsen K
Nat Commun
. 2024 Nov;
15(1):9646.
PMID: 39511177
The ability to predict how amino acid changes affect proteins has a wide range of applications including in disease variant classification and protein engineering. Many existing methods focus on learning...
10.
Piovesan D, Del Conte A, Mehdiabadi M, Aspromonte M, Blum M, Tesei G, et al.
Nucleic Acids Res
. 2024 Oct;
53(D1):D495-D503.
PMID: 39470701
The MobiDB database (URL: https://mobidb.org/) aims to provide structural and functional information about intrinsic protein disorder, aggregating annotations from the literature, experimental data, and predictions for all known protein sequences....