Barbie K Ganser-Pornillos
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Explore the profile of Barbie K Ganser-Pornillos including associated specialties, affiliations and a list of published articles.
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2844
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Recent Articles
31.
Bhattacharya A, Alam S, Fricke T, Zadrozny K, Sedzicki J, Taylor A, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(52):18625-30.
PMID: 25518861
Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the...
32.
Yeager M, Dryden K, Ganser-Pornillos B
Methods Mol Biol
. 2012 Nov;
955:527-37.
PMID: 23132079
Electron microscopy provides an efficient method for rapidly assessing whether a solution of macromolecules is homogeneous and monodisperse. If the macromolecules can be induced to form two-dimensional crystals that are...
33.
Ganser-Pornillos B, Yeager M, Pornillos O
Adv Exp Med Biol
. 2012 Feb;
726:441-65.
PMID: 22297526
HIV forms spherical, membrane-enveloped, pleomorphic virions, 1,000-1,500 Å in diameter, which contain two copies of its single-stranded, positive-sense RNA genome. Virus particles initially bud from host cells in a noninfectious...
34.
Pornillos O, Ganser-Pornillos B, Yeager M
Nature
. 2011 Jan;
469(7330):424-7.
PMID: 21248851
The mature capsids of human immunodeficiency virus type 1 (HIV-1) and other retroviruses are fullerene shells, composed of the viral CA protein, that enclose the viral genome and facilitate its...
35.
Ganser-Pornillos B, Chandrasekaran V, Pornillos O, Sodroski J, Sundquist W, Yeager M
Proc Natl Acad Sci U S A
. 2010 Dec;
108(2):534-9.
PMID: 21187419
TRIM5α proteins are restriction factors that protect mammalian cells from retroviral infections by binding incoming viral capsids, accelerating their dissociation, and preventing reverse transcription of the viral genome. Individual TRIM5...
36.
Pornillos O, Ganser-Pornillos B, Banumathi S, Hua Y, Yeager M
J Mol Biol
. 2010 Jul;
401(5):985-95.
PMID: 20600115
The human immunodeficiency virus type 1 capsid is modeled as a fullerene cone that is composed of approximately 250 hexamers and 12 pentamers of the viral CA protein. Structures of...
37.
Pornillos O, Ganser-Pornillos B, Kelly B, Hua Y, Whitby F, Stout C, et al.
Cell
. 2009 Jun;
137(7):1282-92.
PMID: 19523676
The mature capsids of HIV and other retroviruses organize and package the viral genome and its associated enzymes for delivery into host cells. The HIV capsid is a fullerene cone:...
38.
Ganser-Pornillos B, Yeager M, Sundquist W
Curr Opin Struct Biol
. 2008 Apr;
18(2):203-17.
PMID: 18406133
HIV assembly and replication proceed through the formation of morphologically distinct immature and mature viral capsids that are organized by the Gag polyprotein (immature) and by the fully processed CA...
39.
Ganser-Pornillos B, Cheng A, Yeager M
Cell
. 2007 Oct;
131(1):70-9.
PMID: 17923088
The capsids of mature retroviruses perform the essential function of organizing the viral genome for efficient replication. These capsids are modeled as fullerene structures composed of closed hexameric arrays of...
40.
Hanson M, Brooun A, Baker K, Jaakola V, Roth C, Chien E, et al.
Protein Expr Purif
. 2007 Aug;
56(1):85-92.
PMID: 17723307
Production of structure-grade mammalian membrane proteins in substantial quantities has been hindered by a lack of methods for effectively profiling multiple constructs expression in higher eukaryotic systems such as insect...