Owen Pornillos
Overview
Explore the profile of Owen Pornillos including associated specialties, affiliations and a list of published articles.
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Articles
52
Citations
3255
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Recent Articles
1.
Schirra R, Dos Santos N, Ganser-Pornillos B, Pornillos O
Viruses
. 2024 Jul;
16(7).
PMID: 39066201
In the fullerene cone HIV-1 capsid, the central channels of the hexameric and pentameric capsomers each contain a ring of arginine (Arg18) residues that perform essential roles in capsid assembly...
2.
Piacentini J, Allen D, Ganser-Pornillos B, Chanda S, Yoh S, Pornillos O
J Mol Biol
. 2023 Dec;
436(4):168409.
PMID: 38128824
Human immunodeficiency virus type 1 (HIV-1) stimulates innate immune responses upon infection, including cyclic GMP-AMP synthase (cGAS) signaling that results in type I interferon production. HIV-1-induced activation of cGAS requires...
3.
Sarkar S, Zadrozny K, Zadorozhnyi R, Russell R, Quinn C, Kleinpeter A, et al.
Nat Commun
. 2023 Mar;
14(1):1237.
PMID: 36871077
HIV-1 maturation inhibitors (MIs), Bevirimat (BVM) and its analogs interfere with the catalytic cleavage of spacer peptide 1 (SP1) from the capsid protein C-terminal domain (CA), by binding to and...
4.
Schirra R, Dos Santos N, Zadrozny K, Kucharska I, Ganser-Pornillos B, Pornillos O
Nat Struct Mol Biol
. 2023 Feb;
30(3):383-390.
PMID: 36759579
The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is controlled by a molecular...
5.
Odongo L, Zadrozny K, Diehl W, Luban J, White J, Ganser-Pornillos B, et al.
Acta Crystallogr F Struct Biol Commun
. 2023 Feb;
79(Pt 2):45-50.
PMID: 36748341
Niemann-Pick C1 protein (NPC1) is a membrane protein that primarily resides in late endosomes and lysosomes, and plays an important role in cholesterol homeostasis in the cell. The second luminal...
6.
Yu A, Lee E, Briggs J, Ganser-Pornillos B, Pornillos O, Voth G
Proc Natl Acad Sci U S A
. 2022 Mar;
119(10):e2117781119.
PMID: 35238630
SignificanceThe mature capsids of HIV-1 are transiently stable complexes that self-assemble around the viral genome during maturation, and uncoat to release preintegration complexes that archive a double-stranded DNA copy of...
7.
Xue G, Braczyk K, Goncalves-Carneiro D, Dawidziak D, Sanchez K, Ong H, et al.
PLoS Pathog
. 2022 Feb;
18(2):e1009202.
PMID: 35130321
Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation. ZAP is active against both DNA and RNA...
8.
Zadorozhnyi R, Sarkar S, Quinn C, Zadrozny K, Ganser-Pornillos B, Pornillos O, et al.
Front Mol Biosci
. 2021 Dec;
8:767040.
PMID: 34957215
Histidine residues play important structural and functional roles in proteins, such as serving as metal-binding ligands, mediating enzyme catalysis, and modulating proton channel activity. Many of these activities are modulated...
9.
Zurowska K, Alam A, Ganser-Pornillos B, Pornillos O
Proteins
. 2021 Aug;
90(1):309-313.
PMID: 34357660
The Gag proteins of retroviruses play an essential role in virus particle assembly by forming a protein shell or capsid and thus generating the virion compartment. A variety of human...
10.
Buckmaster M, Zadrozny K, Ganser-Pornillos B, Pornillos O, Goff S
J Virol
. 2021 Jul;
95(19):e0061521.
PMID: 34287037
The transition from an immature to a fully infectious mature retrovirus particle is associated with molecular switches that trigger dramatic conformational changes in the structure of the Gag proteins. A...