Barbie K Ganser-Pornillos
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Explore the profile of Barbie K Ganser-Pornillos including associated specialties, affiliations and a list of published articles.
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41
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2844
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Recent Articles
21.
Buffone C, Martinez-Lopez A, Fricke T, Opp S, Severgnini M, Cifola I, et al.
J Virol
. 2018 Jul;
92(19).
PMID: 29997211
Human immunodeficiency virus type 1 (HIV-1) displays the unique ability to infect nondividing cells. The capsid of HIV-1 is the viral determinant for viral nuclear import. To understand the cellular...
22.
Wagner J, Christensen D, Bhattacharya A, Dawidziak D, Roganowicz M, Wan Y, et al.
J Virol
. 2017 Dec;
92(4).
PMID: 29187540
Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that...
23.
Roganowicz M, Komurlu S, Mukherjee S, Plewka J, Alam S, Skorupka K, et al.
PLoS Pathog
. 2017 Oct;
13(10):e1006686.
PMID: 29040325
Restriction factors are important components of intrinsic cellular defense mechanisms against viral pathogens. TRIM5α is a restriction factor that intercepts the incoming capsid cores of retroviruses such as HIV and...
24.
Yang S, Kreutzberger A, Kiessling V, Ganser-Pornillos B, White J, Tamm L
Sci Adv
. 2017 Aug;
3(6):e1700338.
PMID: 28782011
It has been proposed that cholesterol in host cell membranes plays a pivotal role for cell entry of HIV. However, it remains largely unknown why virions prefer cholesterol-rich heterogeneous membranes...
25.
Dawidziak D, Sanchez J, Wagner J, Ganser-Pornillos B, Pornillos O
Proteins
. 2017 Jul;
85(10):1957-1961.
PMID: 28681414
Tripartite motif (TRIM) proteins comprise a large family of RING-type ubiquitin E3 ligases that regulate important biological processes. An emerging general model is that TRIMs form elongated antiparallel coiled-coil dimers...
26.
Bayro M, Ganser-Pornillos B, Zadrozny K, Yeager M, Tycko R
J Am Chem Soc
. 2016 Sep;
138(37):12029-32.
PMID: 27593947
Maturation of HIV-1 requires disassembly of the Gag polyprotein lattice, which lines the viral membrane in the immature state, and subsequent assembly of the mature capsid protein lattice, which encloses...
27.
Wagner J, Zadrozny K, Chrustowicz J, Purdy M, Yeager M, Ganser-Pornillos B, et al.
Elife
. 2016 Jul;
5.
PMID: 27416583
Virus assembly and maturation proceed through the programmed operation of molecular switches, which trigger both local and global structural rearrangements to produce infectious particles. HIV-1 contains an assembly and maturation...
28.
Li Y, Chandrasekaran V, Carter S, Woodward C, Christensen D, Dryden K, et al.
Elife
. 2016 Jun;
5.
PMID: 27253068
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin...
29.
Wagner J, Roganowicz M, Skorupka K, Alam S, Christensen D, Doss G, et al.
Elife
. 2016 Jun;
5.
PMID: 27253059
Restriction factors and pattern recognition receptors are important components of intrinsic cellular defenses against viral infection. Mammalian TRIM5α proteins are restriction factors and receptors that target the capsid cores of...
30.
Grime J, Dama J, Ganser-Pornillos B, Woodward C, Jensen G, Yeager M, et al.
Nat Commun
. 2016 May;
7:11568.
PMID: 27174390
The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA....