Avi L Friedlich
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Explore the profile of Avi L Friedlich including associated specialties, affiliations and a list of published articles.
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7
Citations
230
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Recent Articles
1.
Friedlich A, Rolston R, Zhu X, Marlatt M, Castellani R, Nunomura A, et al.
F1000 Med Rep
. 2010 Oct;
1.
PMID: 20948726
Effective therapy for Alzheimer's disease (AD), up to this point, has been hampered by our inability to diagnose the disease in its early stages, before the occurrence of significant neurodegeneration...
2.
Bonda D, Lee H, Lee H, Friedlich A, Perry G, Zhu X, et al.
Curr Opin Drug Discov Devel
. 2010 Mar;
13(2):235-46.
PMID: 20205057
As the most prevalent form of dementia worldwide, Alzheimer's disease (AD) continues to be a burden for patients and their families. In addition, with the global population of aged individuals...
3.
Yi J, Horky L, Friedlich A, Shi Y, Rogers J, Huang X
Int J Clin Exp Pathol
. 2008 Dec;
2(3):211-38.
PMID: 19079617
Alzheimer's disease (AD), the most common form of dementia, is characterized by progressive neurodegeneration and loss of cognitive and memory functions. Although the exact causes of AD are still unclear,...
4.
Rogers J, Bush A, Cho H, Smith D, Thomson A, Friedlich A, et al.
Biochem Soc Trans
. 2008 Nov;
36(Pt 6):1282-7.
PMID: 19021541
The essential metals iron, zinc and copper deposit near the Abeta (amyloid beta-peptide) plaques in the brain cortex of AD (Alzheimer's disease) patients. Plaque-associated iron and zinc are in neurotoxic...
5.
Puglielli L, Friedlich A, Setchell K, Nagano S, Opazo C, Cherny R, et al.
J Clin Invest
. 2005 Aug;
115(9):2556-63.
PMID: 16127459
The abnormal accumulation of amyloid beta-peptide (Abeta) in the form of senile (or amyloid) plaques is one of the main characteristics of Alzheimer disease (AD). Both cholesterol and Cu2+ have...
6.
Friedlich A, Lee J, van Groen T, Cherny R, Volitakis I, Cole T, et al.
J Neurosci
. 2004 Apr;
24(13):3453-9.
PMID: 15056725
Cerebral amyloid angiopathy (CAA) is common in Alzheimer's disease (AD) and may contribute to dementia and cerebral hemorrhage. Parenchymal beta-amyloid deposition is dependent on the activity of zinc transporter 3...
7.
Manfredi G, Kwong J, Oca-Cossio J, Woischnik M, Gajewski C, Martushova K, et al.
J Biol Chem
. 2002 Nov;
278(8):5639-45.
PMID: 12431997
Members of the BCL-2-related antiapoptotic family of proteins have been shown previously to regulate ATP/ADP exchange across the mitochondrial membranes and to prevent the loss of coupled mitochondrial respiration during...