Novel Therapeutics for Alzheimer's Disease: an Update

Overview

Journal Curr Opin Drug Discov Devel

Specialties Chemistry
Pharmacology

Date 2010 Mar 6

PMID 20205057

Citations 17

Authors

David J Bonda

Hyun-pil Lee

Hyoung-gon Lee

Avi L Friedlich

George Perry

Xiongwei Zhu

Mark A Smith

Affiliations

Soon will be listed here.

Abstract

As the most prevalent form of dementia worldwide, Alzheimer's disease (AD) continues to be a burden for patients and their families. In addition, with the global population of aged individuals increasing exponentially, AD represents a significant economic burden to society. The development of an effective approach for the treatment of AD is thus of major importance, as current treatment strategies are limited to agents that attenuate disease symptomatology without addressing the causes of disease. A considerable need exists for the development of an effective therapy to prevent, or at least delay, the progression of AD. Current hypotheses for the pathogenesis of AD are discussed in this review, with a particular emphasis on the implications of these hypotheses with respect to treatment strategies and preventive measures.

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