L-arginine and Alzheimer's Disease

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2008 Dec 17

PMID 19079617

Citations 34

Authors

Jing Yi

Laura L Horky

Avi L Friedlich

Ying Shi

Jack T Rogers

Xudong Huang

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD), the most common form of dementia, is characterized by progressive neurodegeneration and loss of cognitive and memory functions. Although the exact causes of AD are still unclear, evidence suggests that atherosclerosis, redox stress, inflammation, neurotransmitter dysregulation, and impaired brain energy metabolism may all be associated with AD pathogenesis. Herein, we explore a possible role for L-arginine (L-arg) in AD, taking into consideration known functions for L-arg in atherosclerosis, redox stress and the inflammatory process, regulation of synaptic plasticity and neurogenesis, and modulation of glucose metabolism and insulin activity. L-arg, a precursor of nitric oxide and polyamine, exhibits multiple functions in human health and may play a prominent role in age-related degenerative diseases such as AD.

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