Ari Tolonen
Overview
Explore the profile of Ari Tolonen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
66
Citations
725
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hammid A, Fallon J, Vellonen K, Lassila T, Reinisalo M, Urtti A, et al.
Eur J Pharm Sci
. 2023 Oct;
191:106603.
PMID: 37827455
Aldehyde oxidase (AOX) is a cytosolic drug-metabolizing enzyme which has attracted increasing attention in drug development due to its high hepatic expression, broad substrate profile and species differences. In contrast,...
2.
Jyrkas J, Lassila T, Tolonen A
J Pharm Biomed Anal
. 2023 Jan;
225:115219.
PMID: 36630767
Peptide therapeutics showcase number of advantages compared to the traditional small molecule drugs, e,g. they usually have higher affinity to target and lower toxicity profiles. Endogenous peptides are mostly cleared...
3.
Hammid A, Fallon J, Lassila T, Vieiro P, Balla A, Gonzalez F, et al.
Drug Metab Dispos
. 2022 Oct;
50(12):1483-1492.
PMID: 36195336
As a multitissue organ, the eye possesses unique anatomy and physiology, including differential expression of drug-metabolizing enzymes. Several hydrolytic enzymes that play a major role in drug metabolism and bioactivation...
4.
Karpale M, Karajamaki A, Kummu O, Gylling H, Hyotylainen T, Oresic M, et al.
Br J Pharmacol
. 2021 Mar;
178(12):2461-2481.
PMID: 33687065
Background And Purpose: Many drugs and environmental contaminants induce hypercholesterolemia and promote the risk of atherosclerotic cardiovascular disease. We tested the hypothesis that pregnane X receptor (PXR), a xenobiotic-sensing nuclear...
5.
Hammid A, Fallon J, Lassila T, Salluce G, Smith P, Tolonen A, et al.
Mol Pharm
. 2021 Feb;
18(3):1305-1316.
PMID: 33595329
Hydrolytic reactions constitute an important pathway of drug metabolism and a significant route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that greatly enhance their permeation across...
6.
Jyrkas J, Tolonen A
J Pharm Biomed Anal
. 2021 Feb;
196:113921.
PMID: 33548873
The number of approved peptide therapeutics has increased significantly in recent years. Peptide therapeutics have many advances over small molecule drugs, such as higher affinity to target and lower toxicity...
7.
Salonurmi T, Nabil H, Ronkainen J, Hyotylainen T, Hautajarvi H, Savolainen M, et al.
Front Pharmacol
. 2020 Apr;
11:361.
PMID: 32292343
Activation of pregnane X receptor (PXR) elevates circulating 4-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol. Our aim was to elucidate the...
8.
Showande J, Igbinoba S, Kajula M, Hokkanen J, Tolonen A, Adegbolagun O, et al.
J Basic Clin Physiol Pharmacol
. 2019 Apr;
30(3).
PMID: 30951501
Background Hibiscus sabdariffa beverage (HSB) is widely consumed as a medicinal herb and sometimes used concomitantly with drugs. This study evaluated the in vitro inhibitory potential of the aqueous extract...
9.
Showande S, Fakeye T, Kajula M, Hokkanen J, Tolonen A
Food Sci Nutr
. 2019 Jan;
7(1):44-55.
PMID: 30680158
Background: Increasing use of medicinal herbs as nutritional supplements and traditional medicines for the treatment of diabetes, hypertension, hyperlipidemia, and malaria fever with conventional drugs poses possibilities of herb-drug interactions...
10.
Huovinen J, Haj Hussain M, Niemela M, Laaksonen S, Voipio H, Jyrkas J, et al.
J Steroid Biochem Mol Biol
. 2018 Dec;
188:172-184.
PMID: 30562554
Calcipotriol (MC903) is a side chain analogue of the biologically active 1,25-dihydroxyvitamin D [1,25(OH)D]. Due to its anti-inflammatory and anti-proliferative effects on stromal cells, calcipotriol is a promising candidate for...