Timo Rousu
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Explore the profile of Timo Rousu including associated specialties, affiliations and a list of published articles.
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11
Citations
70
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Recent Articles
1.
Lassila T, Rousu T, Mattila S, Chesne C, Pelkonen O, Turpeinen M, et al.
J Pharm Biomed Anal
. 2015 Aug;
115:345-51.
PMID: 26263063
The objective was to compare several in vitro human liver-derived subcellular and cellular incubation systems for the formation of GSH-trapped reactive metabolites. Incubations of pooled human liver microsomes, human liver...
2.
Pelkonen O, Pasanen M, Tolonen A, Koskinen M, Hakkola J, Abass K, et al.
Curr Med Chem
. 2014 Oct;
22(4):538-50.
PMID: 25312212
Drug metabolism can result in the formation of highly reactive metabolites that are known to play a role in toxicity resulting in a significant proportion of attrition during drug development...
3.
Rousu T, Tolonen A
Bioanalysis
. 2012 Mar;
4(5):555-63.
PMID: 22409553
Background: The use of high-resolution MS systems for quantitative bioanalysis is a growing field, even though a clear majority of bioanalytical methods are still based on MS/MS with triple quadrupole...
4.
Zhang H, Soikkeli A, Tolonen A, Rousu T, Hirvonen J, Finel M
Toxicol In Vitro
. 2012 Jan;
26(8):1286-93.
PMID: 22265884
In vitro glucuronidation assays of diclofenac and indomethacin at pH 7.4 are biased by the instability of the glucuronides due to acyl migration. The extent of this acyl migration may...
5.
Kublbeck J, Laitinen T, Jyrkkarinne J, Rousu T, Tolonen A, Abel T, et al.
Biochem Pharmacol
. 2011 Sep;
82(12):1994-2007.
PMID: 21924250
The so-called human xenosensors, constitutive androstane receptor (hCAR), pregnane X receptor (hPXR) and aryl hydrocarbon receptor (hAhR), participate in drug metabolism and transport as well as in several endogenous processes...
6.
Rousu T, Hokkanen J, Pelkonen O, Tolonen A
Front Pharmacol
. 2011 May;
1:10.
PMID: 21607061
Liquid chromatography-mass spectrometry (LC-MS) with generic gradient elution for a large number of chemically different compounds is a common approach in drug development, used to acquire a large amount of...
7.
Rousu T, Tolonen A
Rapid Commun Mass Spectrom
. 2011 Apr;
25(10):1382-90.
PMID: 21504003
Reactive metabolites are estimated to be one of the main reasons behind unexpected drug-induced toxicity, by binding covalently to cell proteins or DNA. Due to their high reactivity and short...
8.
Zhang H, Tolonen A, Rousu T, Hirvonen J, Finel M
Drug Metab Dispos
. 2010 Nov;
39(3):456-64.
PMID: 21098645
Cell differentiation increases UDP-glucuronosyltransferase (UGT) gene expression in Caco-2 cells. Glucuronidation of 13 UGT substrates, 1-naphthol, diclofenac, epitestosterone, estradiol, ethinylestradiol, indomethacin, oxazepam, R- and S-propranolol, propofol, testosterone, trifluoperazine, and zidovudine,...
9.
Rousu T, Herttuainen J, Tolonen A
Rapid Commun Mass Spectrom
. 2010 Mar;
24(7):939-57.
PMID: 20209667
Liquid chromatography in combination with mass spectrometry (LC/MS) is a superior analytical technique for metabolite profiling and identification studies performed in drug discovery and development laboratories. In the early phase...
10.
Pelkonen O, Tolonen A, Rousu T, Tursas L, Turpeinen M, Hokkanen J, et al.
ALTEX
. 2009 Nov;
26(3):214-22.
PMID: 19907907
In vitro methods to produce metabolic information have increasingly been applied in toxicity risk assessment. In the current contract project of JRC/ECVAM In vitro-Toxicology Unit, 55 organic chemicals, mostly drugs...