James C Whisstock
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Explore the profile of James C Whisstock including associated specialties, affiliations and a list of published articles.
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222
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7245
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Recent Articles
1.
Brysland S, Talaulikar D, Hicks S, Hearn J, Ali S, Maqbool M, et al.
Blood Adv
. 2024 Aug;
8(21):5542-5555.
PMID: 39207869
Clinical features in patients with the B-cell lymphoma, Waldenström macroglobulinemia (WM), include cytopenias, immunoglobulin M (IgM)-mediated hyperviscosity, fatigue, bleeding, and bruising. Therapeutics such as Bruton's tyrosine kinase inhibitors (BTKis) exacerbate...
2.
Wiedemeyer S, Wu G, Lang-Henkel H, Whisstock J, Law R, Steinmetzer T
ChemMedChem
. 2024 Aug;
19(23):e202400360.
PMID: 39118493
Two series of macrocyclic inhibitors addressing the S1 pocket and the prime site of the fibrinolytic serine protease plasmin have been developed. In the first series, a P1 tranexamoyl residue...
3.
Cramer D, Yin V, Caval T, Franc V, Yu D, Wu G, et al.
Mol Cell Proteomics
. 2023 Dec;
23(1):100696.
PMID: 38101751
Plasminogen (Plg), the zymogen of plasmin (Plm), is a glycoprotein involved in fibrinolysis and a wide variety of other physiological processes. Plg dysregulation has been implicated in a range of...
4.
Quek A, Cowieson N, Caradoc-Davies T, Conroy P, Whisstock J, Law R
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762561
Plasminogen (Plg) is the inactive form of plasmin (Plm) that exists in two major glycoforms, referred to as glycoforms I and II (GI and GII). In the circulation, Plg assumes...
5.
Jose J, Law R, Leung E, Wai D, Akhlaghi H, Chandrashekaran I, et al.
Eur J Med Chem
. 2023 Sep;
261:115786.
PMID: 37716187
Perforin is a pore-forming protein whose normal function enables cytotoxic T and natural killer (NK) cells to kill virus-infected and transformed cells. Conversely, unwanted perforin activity can also result in...
6.
7.
Cleeve P, Dierickx D, Naegele L, Kannachel R, Burne L, Buckley G, et al.
J Struct Biol
. 2023 Apr;
215(3):107967.
PMID: 37105276
This paper introduces OpenFIBSEM, a universal API to control Focused Ion Beam Scanning Electron Microscopes (FIBSEM). OpenFIBSEM aims to improve the programmability and automation of electron microscopy workflows in structural...
8.
Traore D, Torres V, Akhtar N, Gummer A, Flanigan S, Coulibaly F, et al.
Structure
. 2023 Feb;
31(4):455-463.e4.
PMID: 36841236
Conjugative DNA transfer is a major factor in the dissemination of antibiotic resistance and virulence genes. In the Gram-positive pathogen Clostridium perfringens, the majority of conjugative plasmids share the conserved...
9.
Wiedemeyer S, Wu G, Pham T, Lang-Henkel H, Perez Urzua B, Whisstock J, et al.
ChemMedChem
. 2023 Jan;
18(6):e202200632.
PMID: 36710259
Two series of macrocyclic plasmin inhibitors with a C-terminal benzylamine group were synthesized. The substitution of the N-terminal phenylsulfonyl group of a previously described inhibitor provided two analogues with sub-nanomolar...
10.
Bayly-Jones C, Ho B, Lau C, Leung E, DAndrea L, Lupton C, et al.
Commun Biol
. 2023 Jan;
6(1):42.
PMID: 36639734
The Membrane Attack Complex (MAC) is responsible for forming large β-barrel channels in the membranes of pathogens, such as gram-negative bacteria. Off-target MAC assembly on endogenous tissue is associated with...