Annelien J M Zweemer
Overview
Explore the profile of Annelien J M Zweemer including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
298
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Recent Articles
1.
den Hollander L, Zweemer A, Bequignon O, Hammerl D, Bleijs B, Veenhuizen M, et al.
Biochem Pharmacol
. 2024 Aug;
229:116464.
PMID: 39111604
CC chemokine receptor 2 and CCL2 are highly involved in cancer growth and metastasis, and immune escape. Raised sodium ion concentrations in solid tumours have also been correlated to metastasis...
2.
Coban B, Wang Z, Liao C, Beslmuller K, Timmermans M, Martens J, et al.
iScience
. 2024 May;
27(5):109738.
PMID: 38706844
Tumor tissues often contain high extracellular adenosine, promoting an immunosuppressed environment linked to mesenchymal transition and immune evasion. Here, we show that loss of the epithelial transcription factor, GRHL2, triggers...
3.
Bergonzini C, Gregori A, Hagens T, van der Noord V, van de Water B, Zweemer A, et al.
J Exp Clin Cancer Res
. 2024 Jan;
43(1):4.
PMID: 38163893
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer and the chemotherapies such as gemcitabine/nab-paclitaxel are confronted with intrinsic or acquired resistance. The aim of this...
4.
Bergonzini C, Kroese K, Zweemer A, Danen E
Front Cell Dev Biol
. 2022 Mar;
10:863850.
PMID: 35356286
Integrins mediate adhesive interactions between cells and their environment, including neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane receptors bind extracellular ligands with their globular head domains and connect...
5.
Wagner S, de Moura Gatti F, Silva D, Ortiz Zacarias N, Zweemer A, Hermann S, et al.
ChemMedChem
. 2020 Nov;
16(4):640-645.
PMID: 33205603
Herein we report the design and synthesis of a series of highly selective CCR2 antagonists as F-labeled PET tracers. The derivatives were evaluated extensively for their off-target profile at 48...
6.
Coban B, Bergonzini C, Zweemer A, Danen E
Br J Cancer
. 2020 Nov;
124(1):49-57.
PMID: 33204023
Despite the fact that different genetic programmes drive metastasis of solid tumours, the ultimate outcome is the same: tumour cells are empowered to pass a series of physical hurdles to...
7.
Ortiz Zacarias N, Veldhoven J, Portner L, van Spronsen E, Ullo S, Veenhuizen M, et al.
J Med Chem
. 2018 Sep;
61(20):9146-9161.
PMID: 30256641
The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved...
8.
Zweemer A, French C, Mesfin J, Gordonov S, Meyer A, Lauffenburger D
Mol Cancer Res
. 2017 Sep;
15(12):1656-1666.
PMID: 28923840
Metastases are a major cause of cancer mortality. AXL, a receptor tyrosine kinase aberrantly expressed in many tumors, is a potent oncogenic driver of metastatic cell motility and has been...
9.
Meyer A, Zweemer A, Lauffenburger D
Cell Syst
. 2015 Aug;
1(1):25-36.
PMID: 26236777
The AXL receptor is a TAM (Tyro3, AXL, MerTK) receptor tyrosine kinase (RTK) important in physiological inflammatory processes such as blood clotting, viral infection, and innate immune-mediated cell clearance. Overexpression...
10.
Vilums M, Zweemer A, Dilanchian A, Veldhoven J, de Vries H, Brussee J, et al.
ChemMedChem
. 2015 Jun;
10(7):1249-58.
PMID: 26033831
Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials...