Anja Kerksiek
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Explore the profile of Anja Kerksiek including associated specialties, affiliations and a list of published articles.
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31
Citations
884
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Recent Articles
1.
Fabiano M, Oikawa N, Kerksiek A, Furukawa J, Yagi H, Kato K, et al.
Int J Mol Sci
. 2024 May;
25(10.
PMID: 38791456
Presenilin proteins (PS1 and PS2) represent the catalytic subunit of γ-secretase and play a critical role in the generation of the amyloid β (Aβ) peptide and the pathogenesis of Alzheimer...
2.
Spinedi M, Clark C, Zullo L, Kerksiek A, Pistis G, Castelao E, et al.
iScience
. 2024 Feb;
27(2):109013.
PMID: 38327787
Neurodegenerative, vascular, and dementia diseases are linked to dysregulations in cholesterol metabolism. Dietary plant sterols, or phytosterols, may interfere to neurodegeneration and cognitive decline, and have cholesterol-lowering, anti-inflammatory, and antioxidant...
3.
Kiss R, Chicoine J, Khalil Y, Sladek R, Chen H, Pisaturo A, et al.
J Biol Chem
. 2023 Sep;
299(11):105295.
PMID: 37774976
Loss of functional RAB18 causes the autosomal recessive condition Warburg Micro syndrome. To better understand this disease, we used proximity biotinylation to generate an inventory of potential RAB18 effectors. A...
4.
Clark C, Gholam M, Zullo L, Kerksiek A, Castelao E, von Gunten A, et al.
iScience
. 2023 May;
26(6):106740.
PMID: 37250771
Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may interfere with neurodegeneration and cognitive...
5.
Otto S, Lutjohann D, Kerksiek A, Friedrichs S, Schulze P, Mobius-Winkler S, et al.
Steroids
. 2022 Jul;
187:109079.
PMID: 35835203
Background And Aims: Blood cholesterol levels are regulated by competing mechanisms of cholesterol synthesis, absorption and excretion. Plant sterols are natural constituents of plants, are not synthesized in humans, and...
6.
Vanbrabant K, Van Meel D, Kerksiek A, Friedrichs S, Dubbeldam M, Schepers M, et al.
J Steroid Biochem Mol Biol
. 2021 Jun;
212:105942.
PMID: 34144153
Enhancing the cholesterol turnover in the brain via activation of liver x receptors can restore memory in a mouse model for Alzheimer's disease. The edible Asian brown alga Sargassum fusiforme...
7.
Martens N, Schepers M, Zhan N, Leijten F, Voortman G, Tiane A, et al.
Mar Drugs
. 2021 Apr;
19(4).
PMID: 33801706
We recently found that dietary supplementation with the seaweed , containing the preferential LXRβ-agonist 24(S)-saringosterol, prevented memory decline and reduced amyloid-β (Aβ) deposition in an Alzheimer's disease (AD) mouse model...
8.
Lutjohann D, Stellaard F, Bolukbasi B, Kerksiek A, Parhofer K, Laufs U
Br J Clin Pharmacol
. 2021 Apr;
87(11):4252-4261.
PMID: 33792095
Aims: The serum ratios of the brain-specific oxysterol 24S-hydroxycholesterol (24S-OHC) to cholesterol and to 27-OHC reflect brain cholesterol turnover. We studied the effect of proprotein convertase subtilisin/kexin type 9 monoclonal...
9.
Canet-Pons J, Sen N, Arsovic A, Almaguer-Mederos L, Halbach M, Key J, et al.
Neurobiol Dis
. 2021 Feb;
152:105289.
PMID: 33577922
Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions carry a risk for selective motor neuron degeneration, known as Amyotrophic...
10.
Lutjohann D, Stellaard F, Kerksiek A, Lotsch J, Oertel B
Eur J Clin Pharmacol
. 2020 Nov;
77(5):659-669.
PMID: 33201347
Purpose: The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity. We tested the effect of another...