Andrew D Huber
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Explore the profile of Andrew D Huber including associated specialties, affiliations and a list of published articles.
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39
Citations
431
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Recent Articles
11.
Liu D, Ndongwe T, Ji J, Huber A, Michailidis E, Rice C, et al.
Viruses
. 2023 Apr;
15(4).
PMID: 37112961
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in...
12.
Lin W, Huber A, Poudel S, Li Y, Seetharaman J, Miller D, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(10):e2217804120.
PMID: 36848571
Ligand-binding promiscuity in detoxification systems protects the body from toxicological harm but is a roadblock to drug development due to the difficulty in optimizing small molecules to both retain target...
13.
Poudel S, Huber A, Chen T
Drug Metab Dispos
. 2022 Sep;
51(2):228-236.
PMID: 36116789
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are ligand-activated transcription factors that regulate the expression of drug metabolizing enzymes and drug transporters. Since their discoveries, they have been...
14.
SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1
Huber A, Li Y, Lin W, Galbraith A, Mishra A, Porter S, et al.
ACS Med Chem Lett
. 2022 Aug;
13(8):1311-1320.
PMID: 35978691
We previously reported a specific inverse agonist (SPA70) of the nuclear receptor pregnane X receptor (PXR). However, derivatization of SPA70 yielded only agonists and neutral antagonists, suggesting that inverse agonism...
15.
Bwayi M, Garcia-Maldonado E, Chai S, Xie B, Chodankar S, Huber A, et al.
Nucleic Acids Res
. 2022 Feb;
50(6):3254-3275.
PMID: 35212371
The 48 human nuclear receptors (NRs) form a superfamily of transcription factors that regulate major physiological and pathological processes. Emerging evidence suggests that NR crosstalk can fundamentally change our understanding...
16.
Wang J, Buchman C, Seetharaman J, Miller D, Huber A, Wu J, et al.
J Am Chem Soc
. 2021 Oct;
143(44):18467-18480.
PMID: 34648292
The human cytochrome P450 (CYP) CYP3A4 and CYP3A5 enzymes metabolize more than one-half of marketed drugs. They share high structural and substrate similarity and are often studied together as CYP3A4/5....
17.
Huber A, Wright W, Lin W, Majumder K, Low J, Wu J, et al.
Cell Mol Life Sci
. 2020 Apr;
78(1):317-335.
PMID: 32232515
Pregnane X receptor (PXR) is activated by chemicals to transcriptionally regulate drug disposition and possibly decrease drug efficacy and increase resistance, suggesting therapeutic value for PXR antagonists. We previously reported...
18.
Wright W, Chenge J, Wang J, Girvan H, Yang L, Chai S, et al.
J Med Chem
. 2020 Jan;
63(3):1415-1433.
PMID: 31965799
The human cytochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metabolize most drugs and have high similarities in their structure and substrate preference. Whereas CYP3A4 is predominantly expressed in the liver,...
19.
Lin W, Bwayi M, Wu J, Li Y, Chai S, Huber A, et al.
Mol Pharmacol
. 2019 Dec;
97(3):180-190.
PMID: 31882411
The xenobiotic receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are activated by structurally diverse chemicals to regulate the expression of target genes, and they have overlapping regulation...
20.
Liu D, Tedbury P, Lan S, Huber A, Puray-Chavez M, Ji J, et al.
Viruses
. 2019 Nov;
11(11).
PMID: 31717338
RNA viruses are highly successful pathogens and are the causative agents for many important diseases. To fully understand the replication of these viruses it is necessary to address the roles...