Andrei Chabes
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Explore the profile of Andrei Chabes including associated specialties, affiliations and a list of published articles.
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75
Citations
3414
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Recent Articles
1.
van der Horst S, Kollenstart L, Batte A, Keizer S, Vreeken K, Pandey P, et al.
Nat Commun
. 2025 Feb;
16(1):1416.
PMID: 39915438
Perturbation of DNA replication, for instance by hydroxyurea-dependent dNTP exhaustion, often leads to stalling or collapse of replication forks. This triggers a replication stress response that stabilizes these forks, activates...
2.
Tran P, Mishra P, Williams L, Moskalenko R, Sharma S, Nilsson A, et al.
Nucleic Acids Res
. 2024 Oct;
52(20):12475-12486.
PMID: 39360631
Alterations in deoxyribonucleoside triphosphate (dNTP) pools have been linked to increased mutation rates and genome instability in unicellular organisms and cell cultures. However, the role of dNTP pool changes in...
3.
De Jaime-Soguero A, Hattemer J, Bufe A, Haas A, van den Berg J, van Batenburg V, et al.
Nat Commun
. 2024 Aug;
15(1):7404.
PMID: 39191776
Human development relies on the correct replication, maintenance and segregation of our genetic blueprints. How these processes are monitored across embryonic lineages, and why genomic mosaicism varies during development remain...
4.
Wanrooij P, Chabes A
EMBO J
. 2023 Aug;
42(18):e114990.
PMID: 37548337
The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the...
5.
Dmowski M, Makiela-Dzbenska K, Sharma S, Chabes A, Fijalkowska I
DNA Repair (Amst)
. 2023 Jul;
129:103541.
PMID: 37481989
The generally accepted model assumes that leading strand synthesis is performed by Pol ε, while lagging-strand synthesis is catalyzed by Pol δ. Pol ε has been shown to target the...
6.
Sharma S, Kong Z, Jia S, Tran P, Nilsson A, Chabes A
Methods Mol Biol
. 2023 Feb;
2615:267-280.
PMID: 36807798
Defects in deoxyribonucleoside triphosphate (dNTP) metabolism are associated with a number of mitochondrial DNA (mtDNA) depletion syndromes (MDS). These disorders affect the muscles, liver, and brain, and the concentrations of...
7.
Das B, Mishra P, Pandey P, Sharma S, Chabes A
Cell Metab
. 2022 Dec;
34(12):1895-1896.
PMID: 36476929
A recent publication reported a uniform ∼5- to 6-fold increase in dNTP pools 30 min after exposure to ionizing radiation. Das et al. were not able to reproduce these results....
8.
Dmowski M, Jedrychowska M, Makiela-Dzbenska K, Denkiewicz-Kruk M, Sharma S, Chabes A, et al.
DNA Repair (Amst)
. 2022 Jan;
110:103272.
PMID: 35038632
DNA replication is performed by replisome proteins, which are highly conserved from yeast to humans. The CMG [Cdc45-Mcm2-7-GINS(Psf1-3, Sld5)] helicase unwinds the double helix to separate the leading and lagging...
9.
Batte A, van der Horst S, Tittel-Elmer M, Sun S, Sharma S, van Leeuwen J, et al.
Life Sci Alliance
. 2022 Jan;
5(4).
PMID: 35017203
Eukaryotic cells have evolved a replication stress response that helps to overcome stalled/collapsed replication forks and ensure proper DNA replication. The replication checkpoint protein Mrc1 plays important roles in these...
10.
Ranjbarian F, Sharma S, Falappa G, Taruschio W, Chabes A, Hofer A
Nucleic Acids Res
. 2021 Dec;
50(3):e18.
PMID: 34850106
Information about the cellular concentrations of deoxyribonucleoside triphosphates (dNTPs) is instrumental for mechanistic studies of DNA replication and for understanding diseases caused by defects in dNTP metabolism. The dNTPs are...