Danielle L Watt
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Explore the profile of Danielle L Watt including associated specialties, affiliations and a list of published articles.
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12
Citations
883
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Recent Articles
1.
Tran P, Mishra P, Williams L, Moskalenko R, Sharma S, Nilsson A, et al.
Nucleic Acids Res
. 2024 Oct;
52(20):12475-12486.
PMID: 39360631
Alterations in deoxyribonucleoside triphosphate (dNTP) pools have been linked to increased mutation rates and genome instability in unicellular organisms and cell cultures. However, the role of dNTP pool changes in...
2.
Wanrooij P, Tran P, Thompson L, Carvalho G, Sharma S, Kreisel K, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(25):14306-14313.
PMID: 32513727
Ribonucleotides (rNMPs) incorporated in the nuclear genome are a well-established threat to genome stability and can result in DNA strand breaks when not removed in a timely manner. However, the...
3.
Rentoft M, Lindell K, Tran P, Chabes A, Buckland R, Watt D, et al.
Proc Natl Acad Sci U S A
. 2016 Apr;
113(17):4723-8.
PMID: 27071091
Even small variations in dNTP concentrations decrease DNA replication fidelity, and this observation prompted us to analyze genomic cancer data for mutations in enzymes involved in dNTP metabolism. We found...
4.
Watt D, Buckland R, Lujan S, Kunkel T, Chabes A
Nucleic Acids Res
. 2015 Nov;
44(4):1669-80.
PMID: 26609135
The absolute and relative concentrations of the four dNTPs are key determinants of DNA replication fidelity, yet the consequences of altered dNTP pools on replication fidelity have not previously been...
5.
Buckland R, Watt D, Chittoor B, Nilsson A, Kunkel T, Chabes A
PLoS Genet
. 2014 Dec;
10(12):e1004846.
PMID: 25474551
The fidelity of DNA replication requires an appropriate balance of dNTPs, yet the nascent leading and lagging strands of the nuclear genome are primarily synthesized by replicases that differ in...
6.
Daly J, Bebenek K, Watt D, Richter K, Jiang C, Zhao M, et al.
J Immunol
. 2012 May;
188(11):5528-37.
PMID: 22547703
To test the hypothesis that DNA polymerase ζ participates in Ig hypermutation, we generated two mouse models of Pol ζ function: a B cell-specific conditional knockout and a knock-in strain...
7.
Lazzaro F, Novarina D, Amara F, Watt D, Stone J, Costanzo V, et al.
Mol Cell
. 2012 Jan;
45(1):99-110.
PMID: 22244334
The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside triphosphates (dNTPs) during replication. Misincorporation is limited by the...
8.
Watt D, Johansson E, Burgers P, Kunkel T
DNA Repair (Amst)
. 2011 Jun;
10(8):897-902.
PMID: 21703943
The major replicative DNA polymerases of S. cerevisiae (Pols α, δ, and ɛ) incorporate substantial numbers of ribonucleotides into DNA during DNA synthesis. When these ribonucleotides are not removed in...
9.
Nick McElhinny S, Kumar D, Clark A, Watt D, Watts B, Lundstrom E, et al.
Nat Chem Biol
. 2010 Aug;
6(10):774-81.
PMID: 20729855
Maintaining the chemical identity of DNA depends on ribonucleotide exclusion by DNA polymerases. However, ribonucleotide exclusion during DNA synthesis in vitro is imperfect. To determine whether ribonucleotides are incorporated during...
10.
Nick McElhinny S, Watts B, Kumar D, Watt D, Lundstrom E, Burgers P, et al.
Proc Natl Acad Sci U S A
. 2010 Mar;
107(11):4949-54.
PMID: 20194773
Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that the four rNTPs are in 36- to 190-fold molar excess over their corresponding dNTPs. During DNA synthesis in vitro using...