Thomas A Kunkel
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Explore the profile of Thomas A Kunkel including associated specialties, affiliations and a list of published articles.
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214
Citations
11417
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Recent Articles
1.
Williams J, Lujan S, Arana M, Burkholder A, Tumbale P, Williams R, et al.
Nat Commun
. 2024 Oct;
15(1):8730.
PMID: 39379399
Finalization of eukaryotic nuclear DNA replication relies on DNA ligase 1 (LIG1) to seal DNA nicks generated during Okazaki Fragment Maturation (OFM). Using a mutational reporter in Saccharomyces cerevisiae, we...
2.
Marks S, Zhou Z, Lujan S, Burkholder A, Kunkel T
DNA Repair (Amst)
. 2024 Sep;
143:103768.
PMID: 39332392
We show that the rates of single base substitutions, additions, and deletions across the nuclear genome are strongly increased in a strain harboring a mutator variant of DNA polymerase α...
3.
Lujan S, Garbacz M, Liberti S, Burkholder A, Kunkel T
Nucleic Acids Res
. 2024 Jul;
52(16):9574-9585.
PMID: 39016170
The endonuclease activity of Pms1 directs mismatch repair by generating a nick in the newly replicated DNA strand. Inactivating Pms2, the human homologue of yeast Pms1, increases the chances of...
4.
Kaminski A, Chiruvella K, Ramsden D, Bebenek K, Kunkel T, Pedersen L
DNA Repair (Amst)
. 2024 Mar;
136:103645.
PMID: 38428373
DNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one...
5.
Stroik S, Carvajal-Garcia J, Gupta D, Edwards A, Luthman A, Wyatt D, et al.
Nature
. 2023 Nov;
623(7988):836-841.
PMID: 37968395
Timely repair of chromosomal double-strand breaks is required for genome integrity and cellular viability. The polymerase theta-mediated end joining pathway has an important role in resolving these breaks and is...
6.
Wu S, Longley M, Lujan S, Kunkel T, Copeland W
Methods Mol Biol
. 2023 Feb;
2615:427-441.
PMID: 36807807
Mitochondrial DNA (mtDNA) encodes components essential for cellular respiration. Low levels of point mutations and deletions accumulate in mtDNA during normal aging. However, improper maintenance of mtDNA results in mitochondrial...
7.
Zhou Z, Follonier C, Lujan S, Burkholder A, Zakian V, Kunkel T
Nucleic Acids Res
. 2022 Dec;
50(22):12844-12855.
PMID: 36533450
Pif1 family 5' → 3' DNA helicases are important for replication fork progression and genome stability. The budding yeast Saccharomyces cerevisiae encodes two Pif1 family helicases, Rrm3 and Pif1, both...
8.
Williams J, Wojtaszek J, Appel D, Krahn J, Wallace B, Walsh E, et al.
Cell Rep
. 2022 Oct;
41(1):111448.
PMID: 36198268
Topoisomerase 1 (Top1) incises DNA containing ribonucleotides to generate complex DNA lesions that are resolved by APE2 (Apn2 in yeast). How Apn2 engages and processes this DNA damage is unclear....
9.
10.
Zhou Z, Kunkel T
DNA Repair (Amst)
. 2022 Jul;
117:103369.
PMID: 35850061
The high fidelity of replication of the nuclear DNA genome in eukaryotes involves three processes. Correct rather than incorrect dNTPs are almost always incorporated by the three major replicases, DNA...