Amy Tarangelo
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Explore the profile of Amy Tarangelo including associated specialties, affiliations and a list of published articles.
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13
Citations
938
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Recent Articles
1.
Rodencal J, Kim N, He A, Li V, Lange M, He J, et al.
Cell Chem Biol
. 2023 Nov;
31(2):234-248.e13.
PMID: 37963466
Ferroptosis is a non-apoptotic form of cell death that can be triggered by inhibiting the system x cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4). We have investigated...
2.
Rodencal J, Kim N, Li V, He A, Lange M, He J, et al.
bioRxiv
. 2023 Jul;
PMID: 37502927
Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid peroxidation. Ferroptosis can be induced by system x cystine/glutamate antiporter inhibition or by direct inhibition of the phospholipid...
3.
Kaushik A, Tarangelo A, Boroughs L, Ragavan M, Zhang Y, Wu C, et al.
Sci Adv
. 2022 Dec;
8(50):eabp8293.
PMID: 36525494
Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts...
4.
Solmonson A, Faubert B, Gu W, Rao A, Cowdin M, Menendez-Montes I, et al.
Nature
. 2022 Apr;
604(7905):349-353.
PMID: 35388219
Mammalian embryogenesis requires rapid growth and proper metabolic regulation. Midgestation features increasing oxygen and nutrient availability concomitant with fetal organ development. Understanding how metabolism supports development requires approaches to observe...
5.
Tarangelo A, Rodencal J, Kim J, Magtanong L, Long J, Dixon S
Life Sci Alliance
. 2022 Jan;
5(4).
PMID: 35074928
Nucleotide synthesis is a metabolically demanding process essential for DNA replication and other processes in the cell. Several anticancer drugs that inhibit nucleotide metabolism induce apoptosis. How inhibition of nucleotide...
6.
Valente L, Tarangelo A, Li A, Naciri M, Raj N, Boutelle A, et al.
J Cell Biol
. 2020 Sep;
219(11).
PMID: 32886745
The mechanisms by which TP53, the most frequently mutated gene in human cancer, suppresses tumorigenesis remain unclear. p53 modulates various cellular processes, such as apoptosis and proliferation, which has led...
7.
Magtanong L, Ko P, To M, Cao J, Forcina G, Tarangelo A, et al.
Cell Chem Biol
. 2019 Jan;
26(3):420-432.e9.
PMID: 30686757
The initiation and execution of cell death can be regulated by various lipids. How the levels of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We find...
8.
Tarangelo A, Dixon S
Oncotarget
. 2018 Jun;
9(37):24572-24573.
PMID: 29872487
No abstract available.
9.
Tarangelo A, Magtanong L, Bieging-Rolett K, Li Y, Ye J, Attardi L, et al.
Cell Rep
. 2018 Jan;
22(3):569-575.
PMID: 29346757
How cancer cells respond to nutrient deprivation remains poorly understood. In certain cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell death termed ferroptosis. Recent evidence suggests...
10.
Kim E, Cheng Y, Bolton-Gillespie E, Cai X, Ma C, Tarangelo A, et al.
J Exp Med
. 2017 May;
214(7):1901-1912.
PMID: 28550162
Prolonged exit from quiescence by hematopoietic stem cells (HSCs) progressively impairs their homeostasis in the bone marrow through an unidentified mechanism. We show that Rb proteins, which are major enforcers...