Lauren G Zacharias
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Explore the profile of Lauren G Zacharias including associated specialties, affiliations and a list of published articles.
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24
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1258
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Recent Articles
1.
Cai L, Hammond N, Tasdogan A, Alsamraae M, Yang C, Cameron R, et al.
Cancer Discov
. 2025 Feb;
:OF1-OF15.
PMID: 39960461
Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis...
2.
Praharaj P, Li Y, Mary C, Soflaee M, Ryu K, Kim D, et al.
Sci Adv
. 2025 Jan;
11(4):eads2664.
PMID: 39854463
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial reducing cofactor for reductive biosynthesis and protection from oxidative stress. To fulfill their heightened anabolic and reductive power demands, cancer cells...
3.
Wu Z, Bezwada D, Cai F, Harris R, Ko B, Sondhi V, et al.
Cell Metab
. 2024 Jun;
36(7):1504-1520.e9.
PMID: 38876105
Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various mitochondrial disorders...
4.
Wang X, Menezes C, Jia Y, Xiao Y, Venigalla S, Cai F, et al.
Science
. 2024 Jun;
384(6701):eadj4301.
PMID: 38870309
Mitochondria are critical for proper organ function and mechanisms to promote mitochondrial health during regeneration would benefit tissue homeostasis. We report that during liver regeneration, proliferation is suppressed in electron...
5.
Cai L, Vu H, Gu W, Chen H, Franklin J, Abou Haidar L, et al.
bioRxiv
. 2024 Jan;
PMID: 38168314
Metabolomic profiling is instrumental in understanding the systemic and cellular impact of inborn errors of metabolism (IEMs), monogenic disorders caused by pathogenic genomic variants in genes involved in metabolism. This...
6.
Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang M, et al.
Cell Metab
. 2023 Aug;
35(10):1830-1843.e5.
PMID: 37611583
Stable isotopes are powerful tools to assess metabolism. C labeling is detected using nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS). MS has excellent sensitivity but generally cannot discriminate...
7.
Parida P, Marquez-Palencia M, Ghosh S, Khandelwal N, Kim K, Nair V, et al.
Nat Cancer
. 2023 May;
4(6):893-907.
PMID: 37248394
Disseminated tumor cells with metabolic flexibility to utilize available nutrients in distal organs persist, but the precise mechanisms that facilitate metabolic adaptations remain unclear. Here we show fragmented mitochondrial puncta...
8.
Wu Z, Bezwada D, Harris R, Pan C, Nguyen P, Faubert B, et al.
bioRxiv
. 2023 May;
PMID: 37214913
Cancer cells reprogram their metabolism to support cell growth and proliferation in harsh environments. While many studies have documented the importance of mitochondrial oxidative phosphorylation (OXPHOS) in tumor growth, some...
9.
Kaushik A, Tarangelo A, Boroughs L, Ragavan M, Zhang Y, Wu C, et al.
Sci Adv
. 2022 Dec;
8(50):eabp8293.
PMID: 36525494
Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts...
10.
Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, et al.
Sci Adv
. 2022 Aug;
8(35):eabn9550.
PMID: 36044570
In mice and humans with cancer, intravenous C-glucose infusion results in C labeling of tumor tricarboxylic acid (TCA) cycle intermediates, indicating that pyruvate oxidation in the TCA cycle occurs in...