James A Olzmann
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Explore the profile of James A Olzmann including associated specialties, affiliations and a list of published articles.
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72
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7486
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Recent Articles
1.
Lange M, Wolk M, Doubravsky C, Hendricks J, Kato S, Otoki Y, et al.
bioRxiv
. 2025 Jan;
PMID: 39829838
Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of LD neutral lipids...
2.
Jain A, Heremans I, Rademaker G, Detomasi T, Hernandez G, Zhang J, et al.
bioRxiv
. 2024 Dec;
PMID: 39713462
One Sentence Summary: LyLAP degrades transmembrane proteins to sustain high endocytosis and lysosomal membrane stability in pancreatic cancer.
3.
Berndt C, Alborzinia H, Amen V, Ayton S, Barayeu U, Bartelt A, et al.
Redox Biol
. 2024 Jun;
75:103211.
PMID: 38908072
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids...
4.
Mathiowetz A, Meymand E, Deol K, Parlakgul G, Lange M, Pang S, et al.
bioRxiv
. 2024 Jun;
PMID: 38895340
Imbalances in lipid storage and secretion lead to the accumulation of hepatocyte lipid droplets (LDs) (i.e., hepatic steatosis). Our understanding of the mechanisms that govern the channeling of hepatocyte neutral...
5.
Mathiowetz A, Olzmann J
Nat Cell Biol
. 2024 Mar;
26(3):331-345.
PMID: 38454048
Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding...
6.
Dixon S, Olzmann J
Nat Rev Mol Cell Biol
. 2024 Feb;
25(6):424-442.
PMID: 38366038
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms mediating the execution and regulation of ferroptosis....
7.
Lee N, Park S, Lange M, Tseyang T, Doshi M, Kim T, et al.
Nat Metab
. 2024 Feb;
6(2):343-358.
PMID: 38351124
The canonical biological function of selenium is in the production of selenocysteine residues of selenoproteins, and this forms the basis for its role as an essential antioxidant and cytoprotective micronutrient....
8.
Riepe C, Wachalska M, Deol K, Amaya A, Porteus M, Olzmann J, et al.
Mol Biol Cell
. 2023 Nov;
35(2):ar15.
PMID: 38019608
Over 80% of people with cystic fibrosis (CF) carry the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride ion channel at the apical plasma membrane (PM)...
9.
Rodencal J, Kim N, He A, Li V, Lange M, He J, et al.
Cell Chem Biol
. 2023 Nov;
31(2):234-248.e13.
PMID: 37963466
Ferroptosis is a non-apoptotic form of cell death that can be triggered by inhibiting the system x cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4). We have investigated...
10.
Li Z, Lange M, Dixon S, Olzmann J
Annu Rev Biochem
. 2023 Nov;
93(1):499-528.
PMID: 37963395
Cellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic...