Alfred H Merrill
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Explore the profile of Alfred H Merrill including associated specialties, affiliations and a list of published articles.
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14
Citations
982
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Recent Articles
1.
Melum E, Jiang X, Baker K, Macedo M, Fritsch J, Dowds C, et al.
Nat Immunol
. 2019 Oct;
20(12):1644-1655.
PMID: 31636468
Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids, such as sphingomyelin. We hypothesized that these serve as...
2.
Ferreira N, Engelsby H, Neess D, Kelly S, Volpert G, Merrill A, et al.
J Biol Chem
. 2017 Mar;
292(18):7588-7597.
PMID: 28320857
Ceramide and more complex sphingolipids constitute a diverse group of lipids that serve important roles as structural entities of biological membranes and as regulators of cellular growth, differentiation, and development....
3.
Park W, Park J, Merrill A, Storch J, Pewzner-Jung Y, Futerman A
Biochim Biophys Acta
. 2014 Sep;
1841(12):1754-66.
PMID: 25241943
Ceramide synthase 2 (CerS2) null mice cannot synthesize very-long acyl chain (C22-C24) ceramides resulting in significant alterations in the acyl chain composition of sphingolipids. We now demonstrate that hepatic triacylglycerol...
4.
Merrill A, Dennis E, McDonald J, Fahy E
Adv Nutr
. 2013 Sep;
4(5):565-7.
PMID: 24038259
The lipidome is composed of all of the biomolecules defined as lipids, which encompass compounds of amazing structural diversity and complexity. It has been ∼1 decade since the study of...
5.
Martinez T, Chen X, Bandyopadhyay S, Merrill A, Tansey M
Mol Neurodegener
. 2012 Sep;
7:45.
PMID: 22973882
Background: Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson's disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to...
6.
Lucki N, Li D, Bandyopadhyay S, Wang E, Merrill A, Sewer M
Mol Cell Biol
. 2012 Aug;
32(21):4419-31.
PMID: 22927646
Adrenocorticotropin (ACTH) signaling increases glucocorticoid production by promoting the interaction of transcription factors and coactivator proteins with the promoter of steroidogenic genes. The nuclear receptor steroidogenic factor 1 (SF-1) is...
7.
Lucki N, Bandyopadhyay S, Wang E, Merrill A, Sewer M
Mol Endocrinol
. 2012 Jan;
26(2):228-43.
PMID: 22261821
In H295R human adrenocortical cells, ACTH rapidly activates ceramide (Cer) and sphingosine (SPH) turnover with a concomitant increase in SPH-1-phosphate secretion. These bioactive lipids modulate adrenocortical steroidogenesis, primarily by acting...
8.
Adaptive control model reveals systematic feedback and key molecules in metabolic pathway regulation
Quo C, Moffitt R, Merrill A, Wang M
J Comput Biol
. 2011 Feb;
18(2):169-82.
PMID: 21314456
Robust behavior in metabolic pathways resembles stabilized performance in systems under autonomous control. This suggests we can apply control theory to study existing regulation in these cellular networks. Here, we...
9.
Quehenberger O, Armando A, Brown A, Milne S, Myers D, Merrill A, et al.
J Lipid Res
. 2010 Jul;
51(11):3299-305.
PMID: 20671299
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis...
10.
Andreyev A, Fahy E, Guan Z, Kelly S, Li X, McDonald J, et al.
J Lipid Res
. 2010 Jun;
51(9):2785-97.
PMID: 20574076
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization...