David W Russell
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Explore the profile of David W Russell including associated specialties, affiliations and a list of published articles.
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372
Citations
11390
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Recent Articles
1.
Smith R, Bloomer H, Fink D, Keyvanfar K, Nasimuzzaman M, Sancheznieto F, et al.
Hum Gene Ther
. 2022 Sep;
33(23-24):1293-1304.
PMID: 36094106
gene therapy procedures targeting hematopoietic stem and progenitor cells (HSPCs) predominantly utilize lentivirus-based vectors for gene transfer. We provide the first pre-clinical evidence of the therapeutic utility of a foamy...
2.
Toshikawa H, Ikenaka A, Li L, Nishinaka-Arai Y, Niwa A, Ashida A, et al.
Sci Rep
. 2021 Aug;
11(1):17377.
PMID: 34462463
Down syndrome (DS) is caused by the trisomy of chromosome 21. Among the many disabilities found in individuals with DS is an increased risk of early-onset Alzheimer's disease (AD). Although...
3.
Dalwadi D, Torrens L, Abril-Fornaguera J, Pinyol R, Willoughby C, Posey J, et al.
Mol Ther
. 2021 Feb;
29(2):680-690.
PMID: 33554867
Adeno-associated virus (AAV) integrates into host genomes at low frequency, but when integration occurs in oncogenic hotspots it can cause hepatocellular carcinoma (HCC). Given the possibility of recombinant AAV (rAAV)...
4.
Lanza R, Russell D, Nagy A
Nat Rev Immunol
. 2019 Aug;
19(12):723-733.
PMID: 31417198
The prospect of transplanting cells and tissues without the risk of immune rejection or the need for powerful immunosuppressive drugs is the 'holy grail' of transplantation medicine. Now, with the...
5.
Ruiz-Gutierrez M, Bolukbasi O, Alexe G, Kotini A, Ballotti K, Joyce C, et al.
JCI Insight
. 2019 May;
5.
PMID: 31039138
Monosomy 7 or deletion of 7q (del(7q)) are common clonal cytogenetic abnormalities associated with high grade myelodysplastic syndrome (MDS) arising in inherited and acquired bone marrow failure. Current non-transplant approaches...
6.
Russell D
J Biol Chem
. 2018 Dec;
293(49):18804-18827.
PMID: 30530852
On January 21, 2017, I received an E-mail from Herb Tabor that I had been simultaneously hoping for and dreading for several years: an invitation to write a "Reflections" article...
7.
Hiramoto T, Li L, Funk S, Hirata R, Russell D
Mol Ther
. 2018 Apr;
26(5):1255-1265.
PMID: 29606506
X-linked severe combined immunodeficiency (X-SCID) has been successfully treated by hematopoietic stem cell (HSC) transduction with retroviral vectors expressing the interleukin-2 receptor subunit gamma gene (IL2RG), but several patients developed...
8.
Dang E, McDonald J, Russell D, Cyster J
Cell
. 2017 Oct;
171(5):1057-1071.e11.
PMID: 29033131
Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure....
9.
Logan G, Dane A, Hallwirth C, Smyth C, Wilkie E, Amaya A, et al.
Nat Genet
. 2017 Jun;
49(8):1267-1273.
PMID: 28628105
Vectors based on adeno-associated virus type 2 (AAV2) are powerful tools for gene transfer and genome editing applications. The level of interest in this system has recently surged in response...
10.
Gornalusse G, Hirata R, Funk S, Riolobos L, Lopes V, Manske G, et al.
Nat Biotechnol
. 2017 May;
35(8):765-772.
PMID: 28504668
Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the Beta-2 Microglobulin (B2M) gene...