Alexander Tarakhovsky
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Explore the profile of Alexander Tarakhovsky including associated specialties, affiliations and a list of published articles.
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77
Citations
8026
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Recent Articles
21.
Smale S, Tarakhovsky A, Natoli G
Annu Rev Immunol
. 2014 Feb;
32:489-511.
PMID: 24555473
A fundamental property of cells of the innate immune system is their ability to elicit a transcriptional response to a microbial stimulus or danger signal with a high degree of...
22.
Prinjha R, Tarakhovsky A
Genes Dev
. 2013 Aug;
27(16):1731-8.
PMID: 23964091
Recent advances in the enzymology of transcription and chromatin regulation have led to the discovery of proteins that play a prominent role in cell differentiation and the maintenance of specialized...
23.
Tarakhovsky A
Adv Immunol
. 2013 Jul;
119:107-33.
PMID: 23886066
Immune response to pathogens depends on coordinated regulation of numerous genes that contribute collectively to pathogen elimination and restoration of the integrity of the affected tissue. The pathogen-induced gene expression...
24.
Wang D, Zhang Z, OLoughlin E, Lee T, Houel S, OCarroll D, et al.
Genes Dev
. 2012 Apr;
26(7):693-704.
PMID: 22474261
Argonaute proteins (Ago1-4) are essential components of the microRNA-induced silencing complex and play important roles in both microRNA biogenesis and function. Although Ago2 is the only one with the slicer...
25.
Marazzi I, Ho J, Kim J, Manicassamy B, Dewell S, Albrecht R, et al.
Nature
. 2012 Mar;
483(7390):428-33.
PMID: 22419161
Viral infection is commonly associated with virus-driven hijacking of host proteins. Here we describe a novel mechanism by which influenza virus affects host cells through the interaction of influenza non-structural...
26.
Fang T, Schaefer U, Mecklenbrauker I, Stienen A, Dewell S, Chen M, et al.
J Exp Med
. 2012 Mar;
209(4):661-9.
PMID: 22412156
Effective antiviral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes....
27.
Delgado-Olguin P, Huang Y, Li X, Christodoulou D, Seidman C, Seidman J, et al.
Nat Genet
. 2012 Jan;
44(3):343-7.
PMID: 22267199
Adult-onset diseases can be associated with in utero events, but mechanisms for this remain unknown(1,2). The Polycomb histone methyltransferase Ezh2 stabilizes transcription by depositing repressive marks during development that persist...
28.
Donlin L, Andresen C, Just S, Rudensky E, Pappas C, Kruger M, et al.
Genes Dev
. 2012 Jan;
26(2):114-9.
PMID: 22241783
Protein lysine methylation is one of the most widespread post-translational modifications in the nuclei of eukaryotic cells. Methylated lysines on histones and nonhistone proteins promote the formation of protein complexes...
29.
Hwang C, Choi J, Zhou Z, Flesken-Nikitin A, Tarakhovsky A, Nikitin A
Cell Cycle
. 2011 Nov;
10(22):3834-40.
PMID: 22071625
MET, a receptor protein tyrosine kinase activated by hepatocyte growth factor (HGF), is a crucial determinant of metastatic progression. Recently, we have identified p53 as an important regulator of MET-dependent...
30.
Calado D, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, et al.
Cancer Cell
. 2010 Dec;
18(6):580-9.
PMID: 21156282
Diffuse large B cell lymphoma (DLBCL) comprises disease entities with distinct genetic profiles, including germinal center B cell (GCB)-like and activated B cell (ABC)-like DLBCLs. Major differences between these two...