Alessio Nocentini
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Explore the profile of Alessio Nocentini including associated specialties, affiliations and a list of published articles.
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244
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2409
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Recent Articles
21.
Giovannuzzi S, Chavarria D, Provensi G, Leri M, Bucciantini M, Carradori S, et al.
J Med Chem
. 2024 Mar;
67(5):4170-4193.
PMID: 38436571
We report here the first dual inhibitors of brain carbonic anhydrases (CAs) and monoamine oxidase-B (MAO-B) for the management of Alzheimer's disease. Classical CA inhibitors (CAIs) such as methazolamide prevent...
22.
Fuentes-Aguilar A, Gonzalez-Bakker A, Jovanovic M, Jovanovic Stojanov S, Puerta A, Gargano A, et al.
Bioorg Chem
. 2024 Feb;
145:107168.
PMID: 38354500
Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for the design of selective antiproliferative agents. We have accomplished the conjugation...
23.
De Luca V, Angeli A, Nocentini A, Gratteri P, Pratesi S, Tanini D, et al.
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38256046
The implementation of innovative approaches is crucial in an ongoing endeavor to mitigate the impact of COVID-19 pandemic. The present study examines the strategic application of the SARS-CoV-2 Main Protease...
24.
Tawfik H, Saleh M, Ammara A, Khaleel E, Badi R, Khater Y, et al.
J Med Chem
. 2024 Jan;
67(2):1611-1623.
PMID: 38207099
As a progressive neuropathic condition, glaucoma can cause lifelong blindness if left untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective inhibitors for carbonic anhydrase (CA) isoform II to find effective...
25.
El-Azab A, Abdel-Aziz A, Bua S, Nocentini A, Bakheit A, Alkahtani H, et al.
Saudi Pharm J
. 2023 Nov;
31(12):101866.
PMID: 38033749
In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives...
26.
Giovannuzzi S, Nikitjuka A, Pereira Resende B, Smietana M, Nocentini A, Supuran C, et al.
Bioorg Chem
. 2023 Nov;
143:106976.
PMID: 38000350
Over the last decades, the medicinal chemistry of boron-based compounds has been extensively explored, designing valuable small molecule drugs to tackle diseases and conditions, such as cancer, infections, inflammatory and...
27.
Giovannuzzi S, Marapaka A, Abutaleb N, Carta F, Liang H, Nocentini A, et al.
J Enzyme Inhib Med Chem
. 2023 Nov;
38(1):2284119.
PMID: 37994421
Carbonic anhydrases (CAs) from the pathogenic bacteria and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from (α-NgCA), of...
28.
Masci D, Puxeddu M, Di Magno L, DAmbrosio M, Parisi A, Nalli M, et al.
J Med Chem
. 2023 Oct;
66(21):14824-14842.
PMID: 37902628
We synthesized new pyrrole and indole derivatives as human carbonic anhydrase (hCA) inhibitors with the potential to inhibit the Wnt/β-catenin signaling pathway. The presence of both 1-(4-sulfonamidophenyl) and 3-(3,4,5-trimethoxyphenyl) substituents...
29.
Romagnoli R, De Ventura T, Manfredini S, Baldini E, Supuran C, Nocentini A, et al.
J Enzyme Inhib Med Chem
. 2023 Oct;
38(1):2270180.
PMID: 37850364
A novel library of human carbonic anhydrase (hCA) inhibitors based on the 2-sulfanilamido[1,2,4]triazolo[1,5-]pyrimidine skeleton modified at its 7-position was prepared by an efficient convergent procedure. These derivatives were evaluated for...
30.
Begines P, Bonardi A, Nocentini A, Gratteri P, Giovannuzzi S, Ronca R, et al.
Bioorg Med Chem
. 2023 Sep;
94:117467.
PMID: 37722299
Sulfonamides constitute an important class of classical carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. Herein we have accomplished the conjugation of biotin with an ample number of sulfonamide motifs with the...