Alessio Nocentini
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Explore the profile of Alessio Nocentini including associated specialties, affiliations and a list of published articles.
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244
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2409
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Recent Articles
11.
Nocentini A
Enzymes
. 2024 Sep;
55:143-191.
PMID: 39222990
The increasing prevalence of antibiotic-resistant bacteria necessitates the exploration of novel therapeutic targets. Bacterial carbonic anhydrases (CAs) have been known for decades, but only in the past ten years they...
12.
Bua S, Nocentini A, Bonardi A, Palma G, Ciampi G, Giliberti A, et al.
J Med Chem
. 2024 Aug;
67(17):15892-15907.
PMID: 39207927
We describe here the design and antitumor evaluation of benzofuroxan-based nitric oxide (NO)-donor hybrid derivatives targeting human carbonic anhydrases (hCAs) IX and XII. The most effective compounds, and , demonstrated...
13.
Eldehna W, Elsayed Z, Ammara A, El Hassab M, Almahli H, Fares M, et al.
Int J Biol Macromol
. 2024 Aug;
279(Pt 2):135010.
PMID: 39197616
In today's medical field, there is a growing trend of exploiting a single small molecule to target two different molecular targets concurrently. This approach is proving to be highly effective...
14.
Youse M, Abutaleb N, Nocentini A, Abdelsattar A, Ali F, Supuran C, et al.
J Med Chem
. 2024 Aug;
67(17):15537-15556.
PMID: 39141375
Drug-resistant gonorrhea is caused by the bacterial pathogen , for which there is no recommended oral treatment. We have demonstrated that the FDA-approved human carbonic anhydrase inhibitor ethoxzolamide potently inhibits...
15.
Gallardo M, Arancibia R, Supuran C, Nocentini A, Villaman D, Toro P, et al.
J Inorg Biochem
. 2024 Aug;
260:112689.
PMID: 39121601
In the search of new cymantrenyl- and ferrocenyl-sulfonamides as potencial inhibitors of human carbonic anhydrases (hCAs), four compounds based on N-ethyl or N-methyl benzenesulfonamide units have been obtained. These cymantrenyl...
16.
Braconi L, Riganti C, Parenti A, Cecchi M, Nocentini A, Bartolucci G, et al.
Molecules
. 2024 Jul;
29(14).
PMID: 39064868
A new series of piperazine derivatives were synthesized and studied with the aim of obtaining dual inhibitors of P-glycoprotein (P-gp) and carbonic anhydrase XII (hCA XII) to synergistically overcome the...
17.
Nocentini A, Di Porzio A, Bonardi A, Bazzicalupi C, Petreni A, Biver T, et al.
J Enzyme Inhib Med Chem
. 2024 Jun;
39(1):2366236.
PMID: 38905127
A novel class of compounds designed to hit two anti-tumour targets, G-quadruplex structures and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation of G-quadruplex structures by small...
18.
Gasparrini M, Giovannuzzi S, Nocentini A, Raffaelli N, Supuran C
Expert Opin Ther Pat
. 2024 Jun;
34(7):565-582.
PMID: 38861278
Introduction: Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD) from nicotinamide. In addition to its role as essential redox cofactor, NAD also functions...
19.
Bonardi A, Nocentini A, Giovannuzzi S, Paoletti N, Ammara A, Bua S, et al.
J Med Chem
. 2024 May;
67(11):9613-9627.
PMID: 38776401
The development of antibacterial drugs with new mechanisms of action is crucial in combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC 4.2.1.1) have been validated as promising...
20.
Bua S, Bonardi A, Muk G, Nocentini A, Gratteri P, Supuran C
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38473830
2-Benzo[e][1,2,4]thiadiazin-3(4)-one 1,1-dioxide (BTD) based carbonic anhydrase (CA) inhibitors are here explored as new anti-mycobacterial agents. The chemical features of BTD derivatives meet the criteria for a potent inhibition of β-class...