Clemente Capasso
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Explore the profile of Clemente Capasso including associated specialties, affiliations and a list of published articles.
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269
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3684
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Recent Articles
1.
Baroni C, Bozdag M, Renzi G, De Luca V, Capasso C, Bazzicalupi C, et al.
RSC Med Chem
. 2025 Feb;
PMID: 39935522
Here, we report a small series of dual-targeting compounds that combine the prototypical carbonic anhydrase (CA) zinc-binding sulfonamide moiety with the biguanide group of metformin, an emerging anticancer drug. The...
2.
Giovannuzzi S, De Luca V, Capasso C, Supuran C
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39795973
, the causative agent of toxoplasmosis, is a protozoan parasite capable of infecting a wide range of hosts, posing significant health risks, particularly to immunocompromised individuals and congenital transmission. Current...
3.
Paoletti N, Giovannuzzi S, Bonardi A, De Luca V, Capasso C, Nocentini A, et al.
Arch Pharm (Weinheim)
. 2024 Dec;
358(1):e2400814.
PMID: 39686870
This study investigates aliphatic sulfonamide derivatives as inhibitors of the α-, β-, and γ-class carbonic anhydrase (CA) isoforms from Vibrio cholerae (VchCAs). A series of 26 compounds bearing a triazole...
4.
Ferraroni M, Angeli A, De Luca V, Capasso C, Supuran C
J Struct Biol
. 2024 Dec;
217(1):108154.
PMID: 39647519
Porphyromonas gingivalis, a key pathogen in periodontal, plays a critical role in systemic pathologiesdiseases by evading host defence mechanisms and invading periodontal tissues. Targeting its virulence mechanisms and overcoming drug...
5.
De Luca V, Giovannuzzi S, Capasso C, Supuran C
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596360
is a Gram-negative opportunistic pathogen responsible for severe hospital-associated infections. Owing to its ability to develop resistance to a wide range of antibiotics, novel therapeutic strategies are urgently needed. One...
6.
Marinacci B, DAgostino I, Angeli A, Carradori S, Melfi F, Grande R, et al.
J Med Chem
. 2024 Oct;
67(21):19077-19102.
PMID: 39453626
Ciprofloxacin (CPX) is one of the most employed antibiotics in clinics to date. However, the rise of drug-resistant bacteria is dramatically impairing its efficacy, especially against life-threatening pathogens, such as...
7.
Begines P, Bonardi A, Giovannuzzi S, Nocentini A, Gratteri P, De Luca V, et al.
Chem Biol Interact
. 2024 Oct;
404:111284.
PMID: 39442681
The role of carbonic anhydrases isoforms (CAs) IX and XII in the pathogenesis and progression of many types of solid tumors is well known. In this context, selective CA inhibitors...
8.
Angeli A, De Luca V, Huang X, Winter D, Capasso C, Supuran C, et al.
Arch Biochem Biophys
. 2024 Oct;
761:110182.
PMID: 39413948
Human carbonic anhydrases (hCAs) have essential roles in respiration, acid-base balance, and fluid secretion, with implications in diseases such as glaucoma, epilepsy, obesity, and cancer. Of the fifteen known hCAs,...
9.
Baroni C, DAgostino I, Renzi G, Kilbile J, Tamboli Y, Ferraroni M, et al.
ACS Med Chem Lett
. 2024 Oct;
15(10):1749-1755.
PMID: 39411526
Lasamide is a synthetic precursor and a contaminant of the diuretic Furosemide manufacturing process and represents a highly valuable building block for fragment-based drug discovery approaches. We assessed the ability...
10.
Bonardi A, Nocentini A, De Luca V, Capasso C, Elkaeed E, Eldehna W, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337494
This study proposes a novel therapeutic strategy for cancer management by combining the antitumor effects of hydrogen sulfide (HS) and inhibition of carbonic anhydrases (CAs; EC 4.2.1.1), specifically isoforms IV,...