Paulo Cesar Leal
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Explore the profile of Paulo Cesar Leal including associated specialties, affiliations and a list of published articles.
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20
Citations
453
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Recent Articles
1.
Frederico M, Mascarello A, Gomes Castro A, da Luz G, Altenhofen D, Pires Mendes C, et al.
J Cell Biochem
. 2015 Oct;
117(5):1199-209.
PMID: 26447772
To characterize the role and the mechanism of action of (2E)-N'-(1'-naphthyl)-3,4,5-trimethoxybenzohydrazide (BZD) on incretin secretion, glucose uptake in skeletal muscle and α-glucosidase activity on intestine, targets for glucose homeostasis. It...
2.
Silveira A, Laranjeira A, Libanio Rodrigues G, Leal P, Cardoso B, Barata J, et al.
Oncotarget
. 2015 Apr;
6(15):13105-18.
PMID: 25869207
The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resistance in T-ALL,...
3.
Loch-Neckel G, Bicca M, Leal P, Mascarello A, Siqueira J, Calixto J
Eur J Med Chem
. 2014 Dec;
90:93-100.
PMID: 25461314
Chalcones are important compounds that exhibit multiple biological activities, including anti-inflammatory, antimitotic and antibacterial properties. In the present study, we have analyzed the potential anti-cancer activity of a chalcone named...
4.
Tramontini Gomes de Sousa Cardozo F, Camelini C, Leal P, Kratz J, Nunes R, Mendonca M, et al.
Intervirology
. 2014 Nov;
57(6):375-83.
PMID: 25359160
Objective: To study the anti-herpes simplex virus (HSV) activity of a (1→6)-(1→3)-β-D-glucan isolated from Agaricus brasiliensis fruiting bodies (FR) as well as its chemically sulfated derivative (FR-S). Methods: The antiherpetic...
5.
Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum
Bertoldo J, Domeneghini Chiaradia-Delatorre L, Mascarello A, Leal P, Cordeiro M, Nunes R, et al.
J Enzyme Inhib Med Chem
. 2014 Jun;
30(2):299-307.
PMID: 24964346
Falcipain-2 (FP-2) is a key cysteine protease from the malaria parasite Plasmodium falciparum. Many previous studies have identified FP-2 inhibitors; however, none has yet met the criteria for an antimalarial...
6.
Winter E, Gozzi G, Domeneghini Chiaradia-Delatorre L, Daflon-Yunes N, Terreux R, Gauthier C, et al.
Drug Des Devel Ther
. 2014 Jun;
8:609-19.
PMID: 24920885
A series of chalcones substituted by a quinoxaline unit at the B-ring were synthesized and tested as inhibitors of breast cancer resistance protein-mediated mitoxantrone efflux. These compounds appeared more efficient...
7.
Pimenta A, Domeneghini Chiaradia-Delatorre L, Mascarello A, de Oliveira K, Leal P, Yunes R, et al.
Int J Antimicrob Agents
. 2013 Sep;
42(6):519-23.
PMID: 24016798
New unconventional approaches to the development of antimicrobial drugs must target inhibition of infection stages leading to host colonisation or virulence itself, rather than bacterial viability. Amongst the most promising...
8.
Frederico M, Gomes Castro A, Mascarello A, Pires Mendes C, Kappel V, Stumpf T, et al.
Curr Top Med Chem
. 2012 Nov;
12(19):2049-58.
PMID: 23167794
In this study the in vivo and in vitro antidiabetic effects of four acylhydrazone derivatives were investigated in rats. The secretagogue action, oral glucose tolerance, insulinogenic index and mechanism of...
9.
Mielcke T, Mascarello A, Filippi-Chiela E, Zanin R, Lenz G, Leal P, et al.
Eur J Med Chem
. 2012 Jan;
48:255-64.
PMID: 22209415
Gliomas are the most common and devastating tumors of the central nervous system (CNS). Many pieces of evidence point out the relevance of natural compounds for cancer therapy and prevention,...
10.
Pereira P, Lazarotto L, Leal P, Lopes T, Morrone F, Campos M
Pain
. 2011 Oct;
152(12):2861-2869.
PMID: 22001656
This study investigated the effects of pharmacological inhibition of phosphatidylinositol 3-kinase (PI3K)γ in the pruriceptive, inflammatory, and nociceptive responses induced by trypsin in mice. The animals were orally treated with...