Alessandra DallAgnese
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Explore the profile of Alessandra DallAgnese including associated specialties, affiliations and a list of published articles.
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33
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3442
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Recent Articles
1.
DallAgnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, et al.
Cell
. 2024 Nov;
188(1):207-221.e30.
PMID: 39610243
The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent syndromes associated with pathogenic signaling, such as diabetes and chronic inflammation, where our...
2.
Allu P, Cardamone M, Gomes A, DallAgnese A, Cederquist C, Pan H, et al.
Mol Metab
. 2023 Oct;
78:101825.
PMID: 37852413
Objective: Insulin acts on the liver via changes in gene expression to maintain glucose and lipid homeostasis. This study aimed to the Forkhead box protein K1 (FOXK1) associated gene regulatory...
3.
DallAgnese A, Young R
Trends Cell Biol
. 2023 Sep;
33(12):1010-1013.
PMID: 37775397
Gene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping...
4.
Dejosez M, DallAgnese A, Ramamoorthy M, Platt J, Yin X, Hogan M, et al.
Cell Rep
. 2023 May;
42(5):112505.
PMID: 37182209
Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes...
5.
DallAgnese G, DallAgnese A, Banani S, Codrich M, Malfatti M, Antoniali G, et al.
J Biol Chem
. 2023 May;
299(6):104800.
PMID: 37164156
For cells, it is important to repair DNA damage, such as double-strand and single-strand DNA breaks, because unrepaired DNA can compromise genetic integrity, potentially leading to cell death or cancer....
6.
DallAgnese A, Platt J, Zheng M, Friesen M, DallAgnese G, Blaise A, et al.
Nat Commun
. 2022 Dec;
13(1):7522.
PMID: 36473871
Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into dynamic...
7.
Ma H, Zwaan E, Guo Y, Cejas P, Thiru P, van de Bunt M, et al.
Cell Stem Cell
. 2022 Nov;
29(11):1611.
PMID: 36332573
No abstract available.
8.
Banani S, Afeyan L, Hawken S, Henninger J, DallAgnese A, Clark V, et al.
Dev Cell
. 2022 Jul;
57(14):1776-1788.e8.
PMID: 35809564
A multitude of cellular processes involve biomolecular condensates, which has led to the suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof-of-concept studies have identified specific mutations that cause...
9.
Ma H, Zwaan E, Guo Y, Cejas P, Thiru P, van de Bunt M, et al.
Cell Stem Cell
. 2022 Apr;
29(5):795-809.e11.
PMID: 35452598
To understand the mechanisms regulating the in vitro maturation of hPSC-derived hepatocytes, we developed a 3D differentiation system and compared gene regulatory elements in human primary hepatocytes with those in...
10.
Cejas P, Xie Y, Font-Tello A, Lim K, Syamala S, Qiu X, et al.
Nat Commun
. 2021 Oct;
12(1):5775.
PMID: 34599169
Neuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal differentiation that can arise at different anatomic sites but have strong histological and clinical similarities. Here we report the chromatin landscapes...