Brian J Abraham
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Explore the profile of Brian J Abraham including associated specialties, affiliations and a list of published articles.
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73
Citations
13184
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Recent Articles
1.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
Nat Commun
. 2025 Feb;
16(1):2036.
PMID: 40021625
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
2.
Weichert-Leahey N, Zimmerman M, Berezovskaya A, Look A, Abraham B
Bio Protoc
. 2024 Nov;
14(21):e5106.
PMID: 39525967
Genome-wide gene expression analysis is a commonly used method to quantitatively examine the transcriptional signature of any tissue or cell state. Standard bulk cell RNA sequencing (RNA-seq) quantifies RNAs in...
3.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
bioRxiv
. 2024 May;
PMID: 38798584
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
4.
Babu S, Chen J, Robitschek E, Baron C, McConnell A, Wu C, et al.
bioRxiv
. 2024 May;
PMID: 38712250
Mucosal melanoma (MM) is a deadly cancer derived from mucosal melanocytes. To test the consequences of MM genetics, we developed a zebrafish model in which all melanocytes experienced CCND1 expression...
5.
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition
Shendy N, Bikowitz M, Sigua L, Zhang Y, Mercier A, Khashana Y, et al.
Nat Commun
. 2024 Apr;
15(1):3483.
PMID: 38664416
Chemical discovery efforts commonly target individual protein domains. Many proteins, including the EP300/CBP histone acetyltransferases (HATs), contain several targetable domains. EP300/CBP are critical gene-regulatory targets in cancer, with existing high...
6.
Prutsch N, He S, Berezovskaya A, Durbin A, Dharia N, Maher K, et al.
Cell Rep Med
. 2024 Mar;
5(3):101472.
PMID: 38508140
Anaplastic large cell lymphoma (ALCL) is an aggressive, CD30 T cell lymphoma of children and adults. ALK fusion transcripts or mutations in the JAK-STAT pathway are observed in most ALCL...
7.
Searcy M, Larsen 4th R, Stevens B, Zhang Y, Jin H, Drummond C, et al.
Nat Commun
. 2023 Nov;
14(1):7291.
PMID: 37968277
Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1 (P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS histologically resembles developing muscle yet occurs throughout the body...
8.
Weichert-Leahey N, Shi H, Tao T, Oldridge D, Durbin A, Abraham B, et al.
J Clin Invest
. 2023 May;
133(10).
PMID: 37183825
Childhood neuroblastomas exhibit plasticity between an undifferentiated neural crest-like mesenchymal cell state and a more differentiated sympathetic adrenergic cell state. These cell states are governed by autoregulatory transcriptional loops called...
9.
Dejosez M, DallAgnese A, Ramamoorthy M, Platt J, Yin X, Hogan M, et al.
Cell Rep
. 2023 May;
42(5):112505.
PMID: 37182209
Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes...
10.
Insco M, Abraham B, Dubbury S, Kaltheuner I, Dust S, Wu C, et al.
Science
. 2023 Apr;
380(6642):eabn7625.
PMID: 37079685
RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 () is mutated in melanoma, and...