Alessandra DallAgnese
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Explore the profile of Alessandra DallAgnese including associated specialties, affiliations and a list of published articles.
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33
Citations
3442
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Recent Articles
11.
Bisceglie L, Hopp A, Gunasekera K, Wright R, Le Dily F, Vidal E, et al.
iScience
. 2021 May;
24(5):102432.
PMID: 33997706
While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts promotes...
12.
Sheppard H, DallAgnese A, Park W, Shamim M, Dubrulle J, Johnson H, et al.
Cell Rep Med
. 2021 Feb;
2(1):100188.
PMID: 33521702
Chordomas are rare spinal tumors addicted to expression of the developmental transcription factor brachyury. In chordomas, brachyury is super-enhancer associated and preferentially downregulated by pharmacologic transcriptional CDK inhibition, leading to...
13.
Li C, Coffey E, DallAgnese A, Hannett N, Tang X, Henninger J, et al.
Nature
. 2020 Jul;
586(7829):440-444.
PMID: 32698189
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing. Mutations in the MECP2 gene cause the progressive...
14.
Sabari B, DallAgnese A, Young R
Trends Biochem Sci
. 2020 Jul;
45(11):961-977.
PMID: 32684431
Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their...
15.
Klein I, Boija A, Afeyan L, Hawken S, Fan M, DallAgnese A, et al.
Science
. 2020 Jun;
368(6497):1386-1392.
PMID: 32554597
The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we investigated whether condensates concentrate small-molecule cancer therapeutics such that their pharmacodynamic properties are...
16.
Zamudio A, DallAgnese A, Henninger J, Manteiga J, Afeyan L, Hannett N, et al.
Mol Cell
. 2019 Sep;
76(5):753-766.e6.
PMID: 31563432
The gene expression programs that define the identity of each cell are controlled by master transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, which bring extracellular...
17.
DallAgnese A, Caputo L, Nicoletti C, di Iulio J, Schmitt A, Gatto S, et al.
Mol Cell
. 2019 Sep;
76(3):453-472.e8.
PMID: 31519520
MYOD-directed fibroblast trans-differentiation into skeletal muscle provides a unique model to investigate how one transcription factor (TF) reconfigures the three-dimensional chromatin architecture to control gene expression, which is otherwise achieved...
18.
Song Y, van den Berg P, Markoulaki S, Soldner F, DallAgnese A, Henninger J, et al.
Mol Cell
. 2019 Aug;
75(5):905-920.e6.
PMID: 31422875
Variable levels of DNA methylation have been reported at tissue-specific differential methylation regions (DMRs) overlapping enhancers, including super-enhancers (SEs) associated with key cell identity genes, but the mechanisms responsible for...
19.
Guo Y, Manteiga J, Henninger J, Sabari B, DallAgnese A, Hannett N, et al.
Nature
. 2019 Aug;
572(7770):543-548.
PMID: 31391587
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex. The large subunit of Pol ...
20.
Sala D, Cunningham T, Stec M, Etxaniz U, Nicoletti C, DallAgnese A, et al.
Nat Commun
. 2019 Apr;
10(1):1796.
PMID: 30996264
Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation. However, the mechanisms that promote...