Jonathan E Henninger
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Explore the profile of Jonathan E Henninger including associated specialties, affiliations and a list of published articles.
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15
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1281
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Recent Articles
1.
Banani S, Goychuk A, Natarajan P, Zheng M, DallAgnese G, Henninger J, et al.
bioRxiv
. 2024 Nov;
PMID: 39498261
Biomolecular condensates are membraneless compartments that organize biochemical processes in cells. In contrast to well-understood mechanisms describing how condensates form and dissolve, the principles underlying condensate patterning - including their...
2.
Henninger J, Young R
Mol Cell
. 2024 Oct;
84(19):3627-3643.
PMID: 39366351
Foundational models of transcriptional regulation involve the assembly of protein complexes at DNA elements associated with specific genes. These assemblies, which can include transcription factors, cofactors, RNA polymerase, and various...
3.
Oksuz O, Henninger J, Warneford-Thomson R, Zheng M, Erb H, Vancura A, et al.
Mol Cell
. 2023 Jul;
83(14):2449-2463.e13.
PMID: 37402367
Transcription factors (TFs) orchestrate the gene expression programs that define each cell's identity. The canonical TF accomplishes this with two domains, one that binds specific DNA sequences and the other...
4.
DallAgnese A, Platt J, Zheng M, Friesen M, DallAgnese G, Blaise A, et al.
Nat Commun
. 2022 Dec;
13(1):7522.
PMID: 36473871
Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into dynamic...
5.
Banani S, Afeyan L, Hawken S, Henninger J, DallAgnese A, Clark V, et al.
Dev Cell
. 2022 Jul;
57(14):1776-1788.e8.
PMID: 35809564
A multitude of cellular processes involve biomolecular condensates, which has led to the suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof-of-concept studies have identified specific mutations that cause...
6.
Neumayr C, Haberle V, Serebreni L, Karner K, Hendy O, Boija A, et al.
Nature
. 2022 Jun;
606(7913):406-413.
PMID: 35650434
All multicellular organisms rely on differential gene transcription regulated by genomic enhancers, which function through cofactors that are recruited by transcription factors. Emerging evidence suggests that not all cofactors are...
7.
Cable J, Heard E, Hirose T, Prasanth K, Chen L, Henninger J, et al.
Ann N Y Acad Sci
. 2021 Nov;
1506(1):118-141.
PMID: 34791665
The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs...
8.
Sharp P, Chakraborty A, Henninger J, Young R
RNA
. 2021 Nov;
28(1):52-57.
PMID: 34772787
Macroscopic membraneless organelles containing RNA such as the nucleoli, germ granules, and the Cajal body have been known for decades. These biomolecular condensates are liquid-like bodies that can be formed...
9.
Henninger J, Oksuz O, Shrinivas K, Sagi I, LeRoy G, Zheng M, et al.
Cell
. 2020 Dec;
184(1):207-225.e24.
PMID: 33333019
Regulation of biological processes typically incorporates mechanisms that initiate and terminate the process and, where understood, these mechanisms often involve feedback control. Regulation of transcription is a fundamental cellular process...
10.
Li C, Coffey E, DallAgnese A, Hannett N, Tang X, Henninger J, et al.
Nature
. 2020 Jul;
586(7829):440-444.
PMID: 32698189
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing. Mutations in the MECP2 gene cause the progressive...