Aleksandr Obikhod
Overview
Explore the profile of Aleksandr Obikhod including associated specialties, affiliations and a list of published articles.
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16
Citations
176
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Recent Articles
1.
Bourdin C, McGuigan C, Brancale A, Chamberlain S, Vernachio J, Hutchins J, et al.
Bioorg Med Chem Lett
. 2013 Mar;
23(7):2260-4.
PMID: 23453067
7-Deazapurines are known to possess broad antiviral activity, however the 2'-C-methylguanosine analogue displays poor cell permeation and limited phosphorylation, thus is not an efficient inhibitor of hepatitis C virus (HCV)...
2.
Schinazi R, Bassit L, Clayton M, Sun B, Kohler J, Obikhod A, et al.
Antimicrob Agents Chemother
. 2012 Sep;
56(12):6186-91.
PMID: 22985879
Next-generation therapies for chronic hepatitis B virus (HBV) infection will involve combinations of established and/or experimental drugs. The current study investigated the in vitro and in vivo efficacy of tenofovir...
3.
McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, et al.
J Med Chem
. 2011 Nov;
54(24):8632-45.
PMID: 22039920
We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2'-C-methyl guanosines, with significant variation in the diamidate structure. Both symmetrical and...
4.
van Maarseveen N, Wensing A, De Jong D, Beilhartz G, Obikhod A, Tao S, et al.
Antivir Ther
. 2011 Oct;
16(7):1123-30.
PMID: 22024528
Background: HIV-HBV-coinfected individuals who need to be treated only for their HBV infection have limited therapeutic options, since most approved anti-HBV agents have a risk of selecting for drug-resistant HIV...
5.
Herman B, Schinazi R, Zhang H, Nettles J, Stanton R, Detorio M, et al.
Nucleic Acids Res
. 2011 Sep;
40(1):381-90.
PMID: 21914723
β-D-3'-Azido-2',3'-dideoxyguanosine (3'-azido-ddG) is a potent inhibitor of HIV-1 replication with a superior resistance profile to zidovudine. Recently, we identified five novel 6-modified-3'-azido-ddG analogs that exhibit similar or superior anti-HIV-1 activity...
6.
Zhang H, Detorio M, Herman B, Solomon S, Bassit L, Nettles J, et al.
Eur J Med Chem
. 2011 Jun;
46(9):3832-44.
PMID: 21700368
Microwave-assisted optimized transglycosylation reactions were used to prepare eleven modified l-3'-azido-2',3'-dideoxypurine nucleosides. These l-nucleoside analogs were evaluated against HIV and hepatitis B virus. The l-3'-azido-2',3'-dideoxypurines nucleosides were metabolized to nucleoside...
7.
Roy V, Obikhod A, Zhang H, Coats S, Herman B, Sluis-Cremer N, et al.
Nucleosides Nucleotides Nucleic Acids
. 2011 May;
30(4):264-70.
PMID: 21623540
A series of hitherto unknown 3'-α-[1,2,3]-substituted triazolo-2',3'-dideoxypyrimidine nucleoside analogues of the anti-HIV 3'-azido-3'-deoxythymidine (AZT) were synthesized through catalyzed alkyne-azide 1,3-dipolar cycloaddition (Huisgen reaction). Those 3'-[1,2,3]-triazolo analogues bearing an azido alkyl...
8.
Fromentin E, Gavegnano C, Obikhod A, Schinazi R
Anal Chem
. 2010 Feb;
82(5):1982-9.
PMID: 20143781
Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps to inhibit the human immunodeficiency virus type 1 (HIV-1). NRTI-triphosphates (NRTI-TP) compete with endogenous 2'-deoxyribonucleosides-5'-triphosphates (dNTP) for...
9.
Zhang H, Coats S, Bondada L, Amblard F, Detorio M, Asif G, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(1):60-4.
PMID: 19948402
Based on the promising drug resistance profile and potent anti-HIV activity of beta-d-3'-azido-2',3'-dideoxyguanosine, a series of purine modified nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their...
10.
Fromentin E, Asif G, Obikhod A, Hurwitz S, Schinazi R
J Chromatogr B Analyt Technol Biomed Life Sci
. 2009 Sep;
877(29):3482-8.
PMID: 19740712
A sensitive method was developed and validated for simultaneous measurement of an investigational antiviral nucleoside, Amdoxovir (DAPD), its deaminated metabolite 9-(beta-D-1,3-dioxolan-4-yl)guanine (DXG), and Zidovudine (ZDV) in human plasma. This method...