Aleksandar Poleksic
Overview
Explore the profile of Aleksandar Poleksic including associated specialties, affiliations and a list of published articles.
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23
Citations
167
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Recent Articles
1.
Poleksic A
Sci Rep
. 2023 Jan;
13(1):959.
PMID: 36653463
Past research in computational systems biology has focused more on the development and applications of advanced statistical and numerical optimization techniques and much less on understanding the geometry of the...
2.
Poleksic A
IEEE/ACM Trans Comput Biol Bioinform
. 2021 Feb;
19(4):2377-2384.
PMID: 33591920
Modeling complex biological systems is necessary to understand biochemical interactions behind pharmacological effects of drugs. Successful in silico drug repurposing relies on exploration of diverse biochemical concepts and their relationships,...
3.
Lee B, Zhang S, Poleksic A, Xie L
Front Genet
. 2020 Feb;
10:1381.
PMID: 32063919
Advances in next-generation sequencing and high-throughput techniques have enabled the generation of vast amounts of diverse omics data. These big data provide an unprecedented opportunity in biology, but impose great...
4.
Poleksic A, Xie L
Sci Rep
. 2019 Dec;
9(1):20025.
PMID: 31882773
Due to the aging world population and increasing trend in clinical practice to treat patients with multiple drugs, adverse events (AEs) are becoming a major challenge in drug discovery and...
5.
Poleksic A, Turner C, Dalal R, Gray P, Xie L
Proceedings (IEEE Int Conf Bioinformatics Biomed)
. 2018 Sep;
2017:1809-1814.
PMID: 30197820
Adverse drug reactions (ADRs) represent one of the main health and economic problems in the world. With increasing data on ADRs, there is an increased need for software tools capable...
6.
Lim H, Poleksic A, Xie L
AMIA Jt Summits Transl Sci Proc
. 2018 Jun;
2017:132-141.
PMID: 29888057
Side effects are the second and the fourth leading causes of drug attrition and death in the US. Thus, accurate prediction of side effects and understanding their mechanism of action...
7.
Poleksic A, Xie L
Bioinformatics
. 2018 Apr;
34(16):2835-2842.
PMID: 29617731
Motivation: Adverse drug reactions (ADRs) are one of the main causes of death and a major financial burden on the world's economy. Due to the limitations of the animal model,...
8.
Lim H, Gray P, Xie L, Poleksic A
Sci Rep
. 2016 Dec;
6:38860.
PMID: 27958331
Conventional one-drug-one-gene approach has been of limited success in modern drug discovery. Polypharmacology, which focuses on searching for multi-targeted drugs to perturb disease-causing networks instead of designing selective ligands to...
9.
Lim H, Poleksic A, Yao Y, Tong H, He D, Zhuang L, et al.
PLoS Comput Biol
. 2016 Oct;
12(10):e1005135.
PMID: 27716836
Target-based screening is one of the major approaches in drug discovery. Besides the intended target, unexpected drug off-target interactions often occur, and many of them have not been recognized and...
10.
Poleksic A
Algorithms Mol Biol
. 2015 Oct;
10:27.
PMID: 26504491
Background: Progress in the field of protein three-dimensional structure prediction depends on the development of new and improved algorithms for measuring the quality of protein models. Perhaps the best descriptor...