Hansaim Lim
Overview
Explore the profile of Hansaim Lim including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
144
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0
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Recent Articles
1.
Lim H, Tsai C, Keskin O, Nussinov R, Gursoy A
Bioinformatics
. 2022 Sep;
38(21):4962-4965.
PMID: 36124958
Summary: HMI-PRED 2.0 is a publicly available web service for the prediction of host-microbe protein-protein interaction by interface mimicry that is intended to be used without extensive computational experience. A...
2.
Liu Y, Lim H, Xie L
BMC Bioinformatics
. 2022 May;
23(Suppl 3):158.
PMID: 35501680
Background: Drug discovery is time-consuming and costly. Machine learning, especially deep learning, shows great potential in quantitative structure-activity relationship (QSAR) modeling to accelerate drug discovery process and reduce its cost....
3.
Lim H, Cankara F, Tsai C, Keskin O, Nussinov R, Gursoy A
Curr Opin Struct Biol
. 2022 Feb;
73:102328.
PMID: 35152186
Host-microbiome interactions play significant roles in human health and disease. Artificial intelligence approaches have been developed to better understand and predict the molecular interplay between the host and its microbiome....
4.
Cai T, Lim H, Abbu K, Qiu Y, Nussinov R, Xie L
J Chem Inf Model
. 2021 Mar;
61(4):1570-1582.
PMID: 33757283
Small molecules play a critical role in modulating biological systems. Knowledge of chemical-protein interactions helps address fundamental and practical questions in biology and medicine. However, with the rapid emergence of...
5.
Qiu Y, Lu T, Lim H, Xie L
Bioinformatics
. 2020 Feb;
36(9):2787-2795.
PMID: 32003771
Motivation: LINCS L1000 dataset contains numerous cellular expression data induced by large sets of perturbagens. Although it provides invaluable resources for drug discovery as well as understanding of disease mechanisms,...
6.
Lim H, Xie L
IEEE/ACM Trans Comput Biol Bioinform
. 2020 Jan;
18(1):126-137.
PMID: 31995498
Identifying target genes of transcription factors (TFs) is crucial to understand transcriptional regulation. However, our understanding of genome-wide TF targeting profile is limited due to the cost of large-scale experiments...
7.
Ayed M, Lim H, Xie L
BMC Bioinformatics
. 2019 Dec;
20(Suppl 24):674.
PMID: 31861982
Background: Computational prediction of a phenotypic response upon the chemical perturbation on a biological system plays an important role in drug discovery, and many other applications. Chemical fingerprints are a...
8.
Lim H, He D, Qiu Y, Krawczuk P, Sun X, Xie L
PLoS Comput Biol
. 2019 Jun;
15(6):e1006619.
PMID: 31206508
Many complex diseases such as cancer are associated with multiple pathological manifestations. Moreover, the therapeutics for their treatments often lead to serious side effects. Thus, it is needed to develop...
9.
Lim H, Xie L
ACM BCB
. 2019 May;
2018:1-10.
PMID: 31061989
Identifying the target genes of transcription factors (TFs) is one of the key factors to understand transcriptional regulation. However, our understanding of genome-wide TF targeting profile is limited due to...
10.
Lim H, Xie L
Methods Mol Biol
. 2019 Mar;
1939:199-214.
PMID: 30848463
Systems pharmacology aims to understand drug actions on a multi-scale from atomic details of drug-target interactions to emergent properties of biological network and rationally design drugs targeting an interacting network...