Adrian W R Serohijos
Overview
Explore the profile of Adrian W R Serohijos including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
883
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Recent Articles
21.
Klein E, Serohijos A, Choi J, Shakhnovich E, Pekosz A
PLoS One
. 2014 Apr;
9(4):e93632.
PMID: 24699432
The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age, and unprecedented surveillance of the virus provides the opportunity to better understand...
22.
Serohijos A, Shakhnovich E
Mol Biol Evol
. 2013 Oct;
31(1):165-76.
PMID: 24124208
The patterns of polymorphisms in genomes are imprints of the evolutionary forces at play in nature. In particular, polymorphisms have been extensively used to infer the fitness effects of mutations...
23.
Dasmeh P, Serohijos A, Kepp K, Shakhnovich E
PLoS Comput Biol
. 2013 Mar;
9(3):e1002929.
PMID: 23505347
Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10-20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for...
24.
Serohijos A, Lee S, Shakhnovich E
Biophys J
. 2013 Feb;
104(3):L1-3.
PMID: 23442924
To understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological. Here, we show that under the global selection...
25.
Bershtein S, Mu W, Serohijos A, Zhou J, Shakhnovich E
Mol Cell
. 2012 Dec;
49(1):133-44.
PMID: 23219534
What are the molecular properties of proteins that fall on the radar of protein quality control (PQC)? Here we mutate the E. coli's gene encoding dihydrofolate reductase (DHFR) and replace...
26.
Serohijos A, Rimas Z, Shakhnovich E
Cell Rep
. 2012 Sep;
2(2):249-56.
PMID: 22938865
The consistent observation across all kingdoms of life that highly abundant proteins evolve slowly demonstrates that cellular abundance is a key determinant of protein evolutionary rate. However, other empirical findings,...
27.
Mabanglo M, Serohijos A, Poulter C
Biochemistry
. 2011 Dec;
51(4):917-25.
PMID: 22148590
Isopentenyl phosphate kinase (IPK) catalyzes the phosphorylation of isopentenyl phosphate to form the isoprenoid precursor isopentenyl diphosphate in the archaeal mevalonate pathway. This enzyme is highly homologous to fosfomycin kinase...
28.
Serohijos A, Yin S, Ding F, Gauthier J, Gibson D, Maixner W, et al.
Structure
. 2011 Nov;
19(11):1683-90.
PMID: 22078567
Opioids that stimulate the μ-opioid receptor (MOR1) are the most frequently prescribed and effective analgesics. Here we present a structural model of MOR1. Molecular dynamics simulations show a ligand-dependent increase...
29.
Tsygankov D, Serohijos A, Dokholyan N, Elston T
Biophys J
. 2011 Jul;
101(1):144-50.
PMID: 21723824
The molecular motor dynein is associated with various cellular activities, such as directed transport along microtubules and the rhythmic beating of the axoneme. Because of the size and complexity of...
30.
Serohijos A, Thibodeau P, Dokholyan N
Methods Mol Biol
. 2011 May;
741:347-63.
PMID: 21594796
Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative...