Tamas Hegedus
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Explore the profile of Tamas Hegedus including associated specialties, affiliations and a list of published articles.
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62
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1616
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Recent Articles
1.
Berta B, Tordai H, Lukacs G, Papp B, Enyedi A, Padanyi R, et al.
Sci Rep
. 2024 Sep;
14(1):21200.
PMID: 39261533
The clinical management of severe COVID-19 cases is not yet well resolved. Therefore, it is important to identify and characterize cell signaling pathways involved in virus pathogenesis that can be...
2.
Vaccarin C, Veit G, Hegedus T, Torres O, Chilin A, Lukacs G, et al.
J Med Chem
. 2024 Aug;
67(16):13891-13908.
PMID: 39137389
Cystic fibrosis (CF) is caused by the functional expression defect of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Despite the recent success in CFTR modulator development, the available correctors...
3.
Tordai H, Torres O, Csepi M, Padanyi R, Lukacs G, Hegedus T
Sci Data
. 2024 May;
11(1):495.
PMID: 38744964
Single amino acid substitutions can profoundly affect protein folding, dynamics, and function. The ability to discern between benign and pathogenic substitutions is pivotal for therapeutic interventions and research directions. Given...
4.
Laczko-Dobos H, Bhattacharjee A, Maddali A, Kincses A, Abuammar H, Sebok-Nagy K, et al.
Autophagy
. 2024 Feb;
20(7):1639-1650.
PMID: 38411137
The autophagosomal SNARE STX17 (syntaxin 17) promotes lysosomal fusion and degradation, but its autophagosomal recruitment is incompletely understood. Notably, PtdIns4P is generated on autophagosomes and promotes fusion through an unknown...
5.
Soya N, Xu H, Roldan A, Yang Z, Ye H, Jiang F, et al.
bioRxiv
. 2023 Oct;
PMID: 37905074
One-sentence Summary: Allosteric interdomain communication and its modulation are critical determinants of ABCC-transporters post-translational conformational biogenesis, misfolding, and pharmacological rescue.
6.
Soya N, Xu H, Roldan A, Yang Z, Ye H, Jiang F, et al.
Nat Commun
. 2023 Oct;
14(1):6868.
PMID: 37891162
The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide binding domains (NBD1,2)...
7.
Mozner O, Zambo B, Bartos Z, Gergely A, Szabo K, Jezso B, et al.
Membranes (Basel)
. 2023 Oct;
13(10).
PMID: 37887994
The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this...
8.
Basu S, Hegedus T, Kurgan L
J Mol Biol
. 2023 Sep;
435(21):168272.
PMID: 37709009
Molecular recognition features (MoRFs) are a commonly occurring type of intrinsically disordered regions (IDRs) that undergo disorder-to-order transition upon binding to partner molecules. We focus on recently characterized and functionally...
9.
Singh K, Patil R, Patel V, Remenyik J, Hegedus T, Goda K
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511101
The human ABCB1 (P-glycoprotein, Pgp) protein is an active exporter expressed in the plasma membrane of cells forming biological barriers. In accordance with its broad substrate spectrum and tissue expression...
10.
Somogyi A, Vegh D, Roth I, Hegedus T, Schmidt P, Hermann P, et al.
Dent J (Basel)
. 2023 May;
11(5).
PMID: 37232777
Introduction: This article describes the authors' digital workflow-based method for fabricating intraoral occlusal splints, from planning to the evaluation phase. Materials And Methods: In our protocol, first, we had a...