Adrian W R Serohijos
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Explore the profile of Adrian W R Serohijos including associated specialties, affiliations and a list of published articles.
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39
Citations
883
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Recent Articles
11.
Gauthier L, Di Franco R, Serohijos A
Bioinformatics
. 2019 Mar;
35(20):4053-4062.
PMID: 30873519
Motivation: Protein evolution is determined by forces at multiple levels of biological organization. Random mutations have an immediate effect on the biophysical properties, structure and function of proteins. These same...
12.
Dasmeh P, Serohijos A
Proteins
. 2018 Jul;
86(12):1242-1250.
PMID: 30039542
The extent of nonadditive interaction among mutations or epistasis reflects the ruggedness of the fitness landscape, the mapping of genotype to reproductive fitness. In protein evolution, there is strong support...
13.
Rotem A, Serohijos A, Chang C, Wolfe J, Fischer A, Mehoke T, et al.
Mol Biol Evol
. 2018 Jun;
35(10):2390-2400.
PMID: 29955873
Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the landscape and the evolutionary forces on it remain elusive....
14.
Dasmeh P, Girard E, Serohijos A
Sci Rep
. 2017 Nov;
7(1):15844.
PMID: 29158562
Epistasis or the non-additivity of mutational effects is a major force in protein evolution, but it has not been systematically quantified at the level of a proteome. Here, we estimated...
15.
Cheron N, Serohijos A, Choi J, Shakhnovich E
Protein Sci
. 2016 Mar;
25(7):1332-40.
PMID: 26939576
Viruses constantly face the selection pressure of antibodies, either from innate immune response of the host or from administered antibodies for treatment. We explore the interplay between the biophysical properties...
16.
Bershtein S, Serohijos A, Bhattacharyya S, Manhart M, Choi J, Mu W, et al.
PLoS Genet
. 2015 Oct;
11(10):e1005612.
PMID: 26484862
Horizontal gene transfer (HGT) plays a central role in bacterial evolution, yet the molecular and cellular constraints on functional integration of the foreign genes are poorly understood. Here we performed...
17.
Zhang H, Cockrell S, Kolawole A, Rotem A, Serohijos A, Chang C, et al.
J Virol
. 2015 May;
89(15):7722-34.
PMID: 25972549
Unlabelled: Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks are frequently associated with recombination between circulating strains. Strain genotyping and phylogenetic analyses...
18.
Choi J, Serohijos A, Murphy S, Lucarelli D, Lofranco L, Feldman A, et al.
Biophys J
. 2015 Feb;
108(4):795-798.
PMID: 25692584
It has long been known that solvation plays an important role in protein-protein interactions. Here, we use a minimalistic solvation-based model for predicting protein binding energy to estimate quantitatively the...
19.
Dasmeh P, Serohijos A, Kepp K, Shakhnovich E
Genome Biol Evol
. 2014 Oct;
6(10):2956-67.
PMID: 25355808
Understanding the relative contributions of various evolutionary processes-purifying selection, neutral drift, and adaptation-is fundamental to evolutionary biology. A common metric to distinguish these processes is the ratio of nonsynonymous to...
20.
Serohijos A, Shakhnovich E
Curr Opin Struct Biol
. 2014 Jun;
26:84-91.
PMID: 24952216
The variation among sequences and structures in nature is both determined by physical laws and by evolutionary history. However, these two factors are traditionally investigated by disciplines with different emphasis...