Pouria Dasmeh
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Explore the profile of Pouria Dasmeh including associated specialties, affiliations and a list of published articles.
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29
Citations
181
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Recent Articles
1.
Erdogan A, Dasmeh P, Socha R, Chen J, Life B, Jun R, et al.
Nat Commun
. 2024 Dec;
15(1):10813.
PMID: 39737968
Heritable phenotypic variation plays a central role in evolution by conferring rapid adaptive capacity to populations. Mechanisms that can explain genetic diversity by describing connections between genotype and organismal fitness...
2.
Bigge J, Koebbe L, Giel A, Bornholdt D, Buerfent B, Dasmeh P, et al.
BMC Genomics
. 2024 Dec;
25(1):1168.
PMID: 39623312
Background: Genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to DNA damage response (DDR). By analyzing expression quantitative trait loci (eQTL) upon cell stimulation...
3.
Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler S, Musameh M, et al.
JAMA Cardiol
. 2024 Nov;
10(2):145-154.
PMID: 39504041
Importance: Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist. However, it is unknown which genetic and cardiovascular risk factors might be AS-specific and which could be shared between...
4.
Giel A, Bigge J, Schumacher J, Maj C, Dasmeh P
Mol Biol Evol
. 2024 Jun;
41(7).
PMID: 38865495
Understanding the expression level and evolutionary rate of associated genes with human polygenic diseases provides crucial insights into their disease-contributing roles. In this work, we leveraged genome-wide association studies (GWASs)...
5.
Dasmeh P, Zheng J, Erdogan A, Tokuriki N, Wagner A
Nat Commun
. 2024 Apr;
15(1):3327.
PMID: 38637501
Many organismal traits are genetically determined and covary in evolving populations. The resulting trait correlations can either help or hinder evolvability - the ability to bring forth new and adaptive...
6.
Schmutzer M, Dasmeh P, Wagner A
J Mol Evol
. 2024 Mar;
92(2):104-120.
PMID: 38470504
Virtually all enzymes catalyse more than one reaction, a phenomenon known as enzyme promiscuity. It is unclear whether promiscuous enzymes are more often generalists that catalyse multiple reactions at similar...
7.
Maj C, Eberts A, Schumacher J, Dasmeh P
Sci Rep
. 2024 Feb;
14(1):3752.
PMID: 38355689
Understanding the molecular mechanisms of congenital diseases is challenging due to their occurrence within specific developmental stages. Esophageal malformations are examples of such conditions, characterized by abnormalities in the development...
8.
Ranganathan S, Dasmeh P, Furniss S, Shakhnovich E
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2215828120.
PMID: 37155880
Assemblies of multivalent RNA-binding protein fused in sarcoma (FUS) can exist in the functional liquid-like state as well as less dynamic and potentially toxic amyloid- and hydrogel-like states. How could...
9.
Karve S, Dasmeh P, Zheng J, Wagner A
Nat Ecol Evol
. 2022 Jul;
6(8):1155-1164.
PMID: 35798838
Protein abundance affects the evolution of protein genotypes, but we do not know how it affects the evolution of protein phenotypes. Here we investigate the role of protein abundance in...
10.
Dasmeh P, Doronin R, Wagner A
Genetics
. 2021 Nov;
220(1).
PMID: 34791214
One key feature of proteins that form liquid droplets by phase separation inside a cell is multivalency-the presence of multiple sites that mediate interactions with other proteins. We know little...