Adam P. Sharples
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Explore the profile of Adam P. Sharples including associated specialties, affiliations and a list of published articles.
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52
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1198
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Recent Articles
1.
Pilotto A, Turner D, Mazzolari R, Crea E, Brocca L, Pellegrino M, et al.
Am J Physiol Cell Physiol
. 2024 Nov;
328(1):C258-C272.
PMID: 39570634
Human skeletal muscle displays an epigenetic memory of resistance exercise induced-hypertrophy. It is unknown, however, whether high-intensity interval training (HIIT) also evokes an epigenetic muscle memory. This study used repeated...
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Sharples A
Trends Genet
. 2024 Jul;
40(9):736-738.
PMID: 39003156
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) aims to comprehensively map molecular alterations in response to acute exercise and chronic training. In one of a recent series of papers...
4.
Sharples A, Turner D
Am J Physiol Cell Physiol
. 2023 May;
324(6):C1274-C1294.
PMID: 37154489
Skeletal muscle memory is an exciting phenomenon gaining significant traction across several scientific communities, among exercise practitioners, and the public. Research has demonstrated that skeletal muscle tissue can be "primed"...
5.
Voisin S, Seale K, Jacques M, Landen S, Harvey N, Haupt L, et al.
Aging Cell
. 2023 May;
23(1):e13859.
PMID: 37128843
Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate,...
6.
Gorski P, Turner D, Iraki J, Morton J, Sharples A, Areta J
Am J Physiol Endocrinol Metab
. 2023 Apr;
324(5):E437-E448.
PMID: 37018654
We aimed to investigate the human skeletal muscle (SkM) DNA methylome after exercise in low-carbohydrate (CHO) energy-balance (with high-fat) conditions compared with exercise in low-CHO energy-deficit (with low-fat) conditions. The...
7.
McIntosh M, Sexton C, Godwin J, Ruple B, Michel J, Plotkin D, et al.
Cells
. 2023 Mar;
12(6).
PMID: 36980239
Although transcriptome profiling has been used in several resistance training studies, the associated analytical approaches seldom provide in-depth information on individual genes linked to skeletal muscle hypertrophy. Therefore, a secondary...
8.
Sexton C, Godwin J, McIntosh M, Ruple B, Osburn S, Hollingsworth B, et al.
Cells
. 2023 Jan;
12(2).
PMID: 36672198
We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA responses to one bout of lower load (LL) versus higher load (HL) resistance exercise. Trained college-aged males (...
9.
Gorski P, Raastad T, Ullrich M, Turner D, Hallen J, Savari S, et al.
FASEB J
. 2022 Dec;
37(1):e22720.
PMID: 36542473
Cancer survivors suffer impairments in skeletal muscle in terms of reduced mass and function. Interestingly, human skeletal muscle possesses an epigenetic memory of earlier stimuli, such as exercise. Long-term retention...
10.
Egan B, Sharples A
Physiol Rev
. 2022 Nov;
103(3):2057-2170.
PMID: 36395350
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured exercise training are a potent stimulus for physiological adaptation in many organs. Specifically, in skeletal muscle, remarkable plasticity is...